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- W4382011459 abstract "To explore the chronic injury and its possible mechanism of ionizing radiation on multipotent hematopoietic progenitor cells (MPPs) by determining the related indicators of MPPs in bone marrow of mice post-radiation.Sixteen C57BL/6 adult mice were randomly divided into normal control and irradiation groups, 8 mice in each group. The mice in irradiation group were exposed to 6 Gy X-ray. The proportion of bone marrow MPPs, their apoptosis and proliferation 2 months after irradiation were detected by flow cytometry. Mitochondrial activity and levels of reactive oxygen species (ROS) in each MPPs population were detected by Mitotracker Red and DCFDA probes, and the senescent state of MPPs in the bone marrow was analyzed.Ionizing radiation could reduce the proportion of MPPs in mouse bone marrow. The proportions and numbers of MPP1, MPP3 and MPP4 in the bone marrow were significantly decreased after whole-body irradiation with 6 Gy X-ray (P<0.05). In addition, radiation significantly reduced the colony-forming capacity of MPPs in bone marrow (P<0.05), the proportions of apoptotic cells in the MPP1 and MPP4 cell populations increased significantly in the bone marrow (P<0.05). The activity of mitochondria was significantly reduced in the bone marrow MPP2, MPP3 and MPP4 cell populations compared with that of the control group (P<0.05). It was also found that the radiation could significantly increase the ROS levels of MPPs in bone marrow, and the content of ROS in the MPP2, MPP3 and MPP4 cell population of the bone marrow was significantly increased(P<0.05). The senescent cells ratios of MPP1, MPP3 and MPP4 cells in the bone marrow after irradiation were significantly higher than those in the control group (P<0.05).Ionizing radiation can cause chronic MPPs damage in mice, which is closely associated with persistent oxidative stress, cells apoptosis, and cellular senescence.辐射对小鼠骨髓多能造血祖细胞的慢性损伤.通过测定辐射后小鼠骨髓内多能造血祖细胞相关指标，探索电离辐射对多能造血祖细胞(MPPs)的慢性损伤及可能机制.将16只C57BL/6成年小鼠随机分为正常对照组和照射组，每组8只小鼠，照射组小鼠经6 Gy X-射线全身照射。通过流式细胞术检测照射后2个月小鼠骨髓内多能造血祖细胞比例、细胞凋亡及增殖情况。采用Mitotracker Red探针和DCFDA探针结合流式细胞术分别检测各细胞群的线粒体活性及活性氧（ROS）水平，并分析骨髓内多能造血祖细胞的老化状态.辐射能降低小鼠骨髓多能造血祖细胞的比例，6 Gy X-射线全身辐射后，小鼠骨髓内MPP1、MPP3和MPP4比例和数量显著减少（P<0.05）。辐射后骨髓多能造血祖细胞克隆形成能力显著降低（P<0.05），骨髓内MPP1和MPP4细胞群的凋亡细胞比例显著升高（P<0.05）。与对照组比较，骨髓MPP2、MPP3和MPP4细胞群内线粒体活性均显著降低（P<0.05）。辐射能升高骨髓多能造血祖细胞ROS水平，骨髓中MPP2、MPP3和MPP4细胞群内ROS含量均显著升高（P<0.05）。照射后骨髓内MPP1、MPP3和MPP4细胞群的老化细胞比例较对照组显著升高（P<0.05）.电离辐射可导致小鼠多能造血祖细胞慢性损伤，其损伤与细胞氧化应激、细胞凋亡和细胞老化密切相关." @default.
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- W4382011459 date "2023-06-01" @default.
- W4382011459 modified "2023-10-17" @default.
- W4382011459 title "[Chronic Injury of Mice Bone Marrow Multipotent Hematopoietic Progenitor Cells Induced by Ionizing Radiation]." @default.
- W4382011459 doi "https://doi.org/10.19746/j.cnki.issn.1009-2137.2023.03.038" @default.
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