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• W4382011857 abstract "Genetic information is stored in linear DNA molecules, which are highly folded inside cells. DNA replication along the folded template path yields two sister chromatids that initially occupy the same nuclear region in an intertwined arrangement. Dividing cells must disentangle and condense the sister chromatids into separate bodies such that a microtubule-based spindle can move them to opposite poles. While the spindle-mediated transport of sister chromatids has been studied in detail, the chromosome-intrinsic mechanics presegregating sister chromatids have remained elusive. Here, we show that human sister chromatids resolve extensively already during interphase, in a process dependent on the loop-extruding activity of cohesin, but not that of condensins. Increasing cohesin's looping capability increases sister DNA resolution in interphase nuclei to an extent normally seen only during mitosis, despite the presence of abundant arm cohesion. That cohesin can resolve sister chromatids so extensively in the absence of mitosis-specific activities indicates that DNA loop extrusion is a generic mechanism for segregating replicated genomes, shared across different Structural Maintenance of Chromosomes (SMC) protein complexes in all kingdoms of life." @default.
• W4382011857 created "2023-06-27" @default.
• W4382011857 creator A5008347489 @default.
• W4382011857 creator A5008580990 @default.
• W4382011857 creator A5033972281 @default.
• W4382011857 creator A5040630021 @default.
• W4382011857 creator A5055191083 @default.
• W4382011857 creator A5067477836 @default.
• W4382011857 creator A5073634494 @default.
• W4382011857 date "2023-06-26" @default.
• W4382011857 modified "2023-10-17" @default.
• W4382011857 title "Cohesin‐mediated <scp>DNA</scp> loop extrusion resolves sister chromatids in <scp>G2</scp> phase" @default.
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