Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382011861> ?p ?o ?g. }
- W4382011861 abstract "Abstract To pass on genetic information to the next generation, cells must faithfully replicate their genomes to provide copies for each daughter cell. To synthesise these duplicates, cells employ specialised enzymes called DNA polymerases, which rapidly and accurately replicate nucleic acid polymers. However, most polymerases lack the ability to directly initiate DNA synthesis and required specialised replicases called primases to make short polynucleotide primers, from which they then extend. Replicative primases (eukaryotes and archaea) belong to a functionally diverse enzyme superfamily known as Primase-Polymerases (Prim-Pols), with orthologues present throughout all domains of life. Characterised by a conserved catalytic Prim-Pol domain, these enzymes have evolved various roles in DNA metabolism, including DNA replication, repair, and damage tolerance. Many of these biological roles are fundamentally underpinned by the ability of Prim-Pols to generate primers de novo. This review examines our current understanding of the catalytic mechanisms utilised by Prim-Pols to initiate primer synthesis." @default.
- W4382011861 created "2023-06-27" @default.
- W4382011861 creator A5028011621 @default.
- W4382011861 creator A5035119697 @default.
- W4382011861 creator A5055888908 @default.
- W4382011861 date "2023-07-01" @default.
- W4382011861 modified "2023-10-14" @default.
- W4382011861 title "Primase-polymerases: how to make a primer from scratch" @default.
- W4382011861 cites W1487826023 @default.
- W4382011861 cites W1492178396 @default.
- W4382011861 cites W1514574411 @default.
- W4382011861 cites W1577230381 @default.
- W4382011861 cites W1579328338 @default.
- W4382011861 cites W1674626287 @default.
- W4382011861 cites W1936694663 @default.
- W4382011861 cites W1965692186 @default.
- W4382011861 cites W1973339223 @default.
- W4382011861 cites W1979200451 @default.
- W4382011861 cites W1982886390 @default.
- W4382011861 cites W1993978787 @default.
- W4382011861 cites W1999242162 @default.
- W4382011861 cites W2011670759 @default.
- W4382011861 cites W2018391942 @default.
- W4382011861 cites W2019164451 @default.
- W4382011861 cites W2024669930 @default.
- W4382011861 cites W2036181470 @default.
- W4382011861 cites W2037383718 @default.
- W4382011861 cites W2038185005 @default.
- W4382011861 cites W2041648250 @default.
- W4382011861 cites W2045074917 @default.
- W4382011861 cites W2049147540 @default.
- W4382011861 cites W2049694217 @default.
- W4382011861 cites W2053995121 @default.
- W4382011861 cites W2054850768 @default.
- W4382011861 cites W2057281180 @default.
- W4382011861 cites W2058851785 @default.
- W4382011861 cites W2061294794 @default.
- W4382011861 cites W2062875640 @default.
- W4382011861 cites W2072710826 @default.
- W4382011861 cites W2076532479 @default.
- W4382011861 cites W2079391939 @default.
- W4382011861 cites W2086219095 @default.
- W4382011861 cites W2090081292 @default.
- W4382011861 cites W2098891503 @default.
- W4382011861 cites W2112207222 @default.
- W4382011861 cites W2120866790 @default.
- W4382011861 cites W2121178322 @default.
- W4382011861 cites W2124215787 @default.
- W4382011861 cites W2124764875 @default.
- W4382011861 cites W2127303333 @default.
- W4382011861 cites W2132386714 @default.
- W4382011861 cites W2150661602 @default.
- W4382011861 cites W2245319604 @default.
- W4382011861 cites W2275614981 @default.
- W4382011861 cites W2301391263 @default.
- W4382011861 cites W2323867229 @default.
- W4382011861 cites W2408638299 @default.
- W4382011861 cites W2537276668 @default.
- W4382011861 cites W2546869658 @default.
- W4382011861 cites W2566002255 @default.
- W4382011861 cites W2586407474 @default.
- W4382011861 cites W2619370444 @default.
- W4382011861 cites W2766613343 @default.
- W4382011861 cites W2768277772 @default.
- W4382011861 cites W2794823240 @default.
- W4382011861 cites W2807912500 @default.
- W4382011861 cites W2842681836 @default.
- W4382011861 cites W2900758704 @default.
- W4382011861 cites W2901291288 @default.
- W4382011861 cites W2914339520 @default.
- W4382011861 cites W2922514780 @default.
- W4382011861 cites W3080828129 @default.
- W4382011861 cites W3137197601 @default.
- W4382011861 cites W3167776998 @default.
- W4382011861 cites W3167827241 @default.
- W4382011861 cites W3198430096 @default.
- W4382011861 cites W3204920547 @default.
- W4382011861 cites W4205552210 @default.
- W4382011861 cites W4228997170 @default.
- W4382011861 cites W4229608773 @default.
- W4382011861 cites W4285395337 @default.
- W4382011861 cites W4307804928 @default.
- W4382011861 cites W4327860936 @default.
- W4382011861 cites W4380870958 @default.
- W4382011861 doi "https://doi.org/10.1042/bsr20221986" @default.
- W4382011861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37358261" @default.
- W4382011861 hasPublicationYear "2023" @default.
- W4382011861 type Work @default.
- W4382011861 citedByCount "0" @default.
- W4382011861 crossrefType "journal-article" @default.
- W4382011861 hasAuthorship W4382011861A5028011621 @default.
- W4382011861 hasAuthorship W4382011861A5035119697 @default.
- W4382011861 hasAuthorship W4382011861A5055888908 @default.
- W4382011861 hasBestOaLocation W43820118611 @default.
- W4382011861 hasConcept C104317684 @default.
- W4382011861 hasConcept C141231307 @default.
- W4382011861 hasConcept C156719811 @default.
- W4382011861 hasConcept C178790620 @default.
- W4382011861 hasConcept C185592680 @default.
- W4382011861 hasConcept C194830204 @default.