Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382022336> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4382022336 abstract "Changes in an organism’s environment, genome, or gene expression patterns can lead to changes in its metabolism. The metabolic phenotype can be under selection and contributes to adaptation. However, the networked and convoluted nature of an organism’s metabolism makes relating mutations, metabolic changes, and effects on fitness challenging. To overcome this challenge, we use the Long-Term Evolution Experiment (LTEE) with E. coli as a model to understand how mutations can eventually affect metabolism and perhaps fitness. We used mass-spectrometry to broadly survey the metabolomes of the ancestral strains and all 12 evolved lines. We combined this metabolic data with mutation and expression data to suggest how mutations that alter specific reaction pathways, such as the biosynthesis of nicotinamide adenine dinucleotide, might increase fitness in the system. Our work provides a better understanding of how mutations might affect fitness through the metabolic changes in the LTEE and thus provides a major step in developing a complete genotype-phenotype map for this experimental system." @default.
- W4382022336 created "2023-06-27" @default.
- W4382022336 creator A5040072295 @default.
- W4382022336 creator A5047478706 @default.
- W4382022336 creator A5052280993 @default.
- W4382022336 creator A5062439286 @default.
- W4382022336 creator A5077598643 @default.
- W4382022336 creator A5079071814 @default.
- W4382022336 date "2023-06-26" @default.
- W4382022336 modified "2023-10-03" @default.
- W4382022336 title "Linking genotypic and phenotypic changes in the E. coli Long-Term Evolution Experiment using metabolomics" @default.
- W4382022336 doi "https://doi.org/10.7554/elife.87039.2" @default.
- W4382022336 hasPublicationYear "2023" @default.
- W4382022336 type Work @default.
- W4382022336 citedByCount "0" @default.
- W4382022336 crossrefType "posted-content" @default.
- W4382022336 hasAuthorship W4382022336A5040072295 @default.
- W4382022336 hasAuthorship W4382022336A5047478706 @default.
- W4382022336 hasAuthorship W4382022336A5052280993 @default.
- W4382022336 hasAuthorship W4382022336A5062439286 @default.
- W4382022336 hasAuthorship W4382022336A5077598643 @default.
- W4382022336 hasAuthorship W4382022336A5079071814 @default.
- W4382022336 hasBestOaLocation W43820223361 @default.
- W4382022336 hasConcept C104317684 @default.
- W4382022336 hasConcept C127716648 @default.
- W4382022336 hasConcept C135763542 @default.
- W4382022336 hasConcept C137858568 @default.
- W4382022336 hasConcept C139807058 @default.
- W4382022336 hasConcept C169760540 @default.
- W4382022336 hasConcept C192989942 @default.
- W4382022336 hasConcept C19843653 @default.
- W4382022336 hasConcept C21565614 @default.
- W4382022336 hasConcept C501734568 @default.
- W4382022336 hasConcept C54355233 @default.
- W4382022336 hasConcept C60644358 @default.
- W4382022336 hasConcept C70721500 @default.
- W4382022336 hasConcept C86803240 @default.
- W4382022336 hasConceptScore W4382022336C104317684 @default.
- W4382022336 hasConceptScore W4382022336C127716648 @default.
- W4382022336 hasConceptScore W4382022336C135763542 @default.
- W4382022336 hasConceptScore W4382022336C137858568 @default.
- W4382022336 hasConceptScore W4382022336C139807058 @default.
- W4382022336 hasConceptScore W4382022336C169760540 @default.
- W4382022336 hasConceptScore W4382022336C192989942 @default.
- W4382022336 hasConceptScore W4382022336C19843653 @default.
- W4382022336 hasConceptScore W4382022336C21565614 @default.
- W4382022336 hasConceptScore W4382022336C501734568 @default.
- W4382022336 hasConceptScore W4382022336C54355233 @default.
- W4382022336 hasConceptScore W4382022336C60644358 @default.
- W4382022336 hasConceptScore W4382022336C70721500 @default.
- W4382022336 hasConceptScore W4382022336C86803240 @default.
- W4382022336 hasLocation W43820223361 @default.
- W4382022336 hasOpenAccess W4382022336 @default.
- W4382022336 hasPrimaryLocation W43820223361 @default.
- W4382022336 hasRelatedWork W1503530970 @default.
- W4382022336 hasRelatedWork W1967225297 @default.
- W4382022336 hasRelatedWork W1987062257 @default.
- W4382022336 hasRelatedWork W2004866388 @default.
- W4382022336 hasRelatedWork W2413008905 @default.
- W4382022336 hasRelatedWork W2561920654 @default.
- W4382022336 hasRelatedWork W2749732081 @default.
- W4382022336 hasRelatedWork W4321052100 @default.
- W4382022336 hasRelatedWork W4365142050 @default.
- W4382022336 hasRelatedWork W4365146712 @default.
- W4382022336 isParatext "false" @default.
- W4382022336 isRetracted "false" @default.
- W4382022336 workType "article" @default.