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- W4382045354 abstract "Peresolimab, a humanised IgG1 monoclonal antibody that stimulates programmed cell death protein 1, might be a safe and effective treatment option for people with rheumatoid arthritis, according to a phase 2a, double-blind trial by Jay Tuttle and colleagues. 98 patients with moderate-to-severe rheumatoid arthritis with an inadequate response to, loss of response to, or unacceptable side-effects with conventional synthetic or biological DMARDs were randomly assigned to receive 700 mg peresolimab (n=49), 300 mg peresolimab (n=25), or placebo (n=24) intravenously every 4 weeks. At week 12, the least-squares mean change in the Disease Activity Score for 28 joints (DAS28) based on C-reactive protein (the primary outcome) was −2·09 (SE 0·18) in the 700 mg peresolimab group versus −0·99 (SE 0·26) in the placebo group (difference −1·09 [95% CI −1·73 to −0·46]; p<0·001). Nine (38%) participants in the placebo group, eight (32%) in the 300 mg peresolimab group, and 14 (29%) in the 700 mg peresolimab group, had an adverse event during the treatment period. Cognitive functional therapy with or without movement sensor biofeedback versus usual care for chronic, disabling low back pain (RESTORE): a randomised, controlled, three-arm, parallel group, phase 3, clinical trialCFT can produce large and sustained improvements for people with chronic disabling low back pain at considerably lower societal cost than that of usual care. Full-Text PDF" @default.
- W4382045354 created "2023-06-27" @default.
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- W4382045354 date "2023-07-01" @default.
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- W4382045354 title "Research in Brief" @default.
- W4382045354 doi "https://doi.org/10.1016/s2665-9913(23)00167-4" @default.
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