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- W4382045362 abstract "Abstract Actions from glial cells could affect the readiness and efficacy of learning and memory. Using a mouse cerebellar‐dependent horizontal optokinetic response motor learning paradigm, short‐term memory (STM) formation during the online training period and long‐term memory (LTM) formation during the offline rest period were studied. A large variability of online and offline learning efficacies was found. The early bloomers with booming STM often had a suppressed LTM formation and late bloomers with no apparent acute training effect often exhibited boosted offline learning performance. Anion channels containing LRRC8A are known to release glutamate. Conditional knockout of LRRC8A specifically in astrocytes including cerebellar Bergmann glia resulted in a complete loss of STM formation while the LTM formation during the rest period remained. Optogenetic manipulation of glial activity by channelrhodopsin‐2 or archaerhodopsin‐T (ArchT) during the online training resulted in enhancement or suppression of STM formation, respectively. STM and LTM are likely to be triggered simultaneously during online training, but LTM is expressed later during the offline period. STM appears to be volatile and the achievement during the online training is not handed over to LTM. In addition, we found that glial ArchT photoactivation during the rest period resulted in the augmentation of LTM formation. These data suggest that STM formation and LTM formation are parallel separate processes. Strategies to weigh more on the STM or the LTM could depend on the actions of the glial cells." @default.
- W4382045362 created "2023-06-27" @default.
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- W4382045362 date "2023-06-26" @default.
- W4382045362 modified "2023-09-30" @default.
- W4382045362 title "Glial modulation of the parallel memory formation" @default.
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- W4382045362 doi "https://doi.org/10.1002/glia.24431" @default.
- W4382045362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37364894" @default.
- W4382045362 hasPublicationYear "2023" @default.