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• W4382045462 abstract "Groundbreaking developments have occurred in rheumatology over the past 25 years, including the introduction of the now widely used biologics and Janus kinase inhibitors into therapy. However, glucocorticoids—which have been used to treat inflammatory rheumatic musculoskeletal disorders for 75 years—remain a cornerstone of therapy, despite longstanding debate about their risk–benefit ratio. Although these drugs show rapid and pronounced efficacy in rheumatology, gastroenterology, dermatology, nephrology, and other areas of medicine, they must be used carefully and responsibly owing to their potential for adverse effects. Disputes about how best to use glucocorticoids therefore continued to arise; however, these sometimes very emotional discussions have calmed over the past decade. The consensus accepted by almost all rheumatologists is to use the lowest dose for the shortest time possible to deliver the required benefit. 1 Buttgereit F Views on glucocorticoid therapy in rheumatology: the age of convergence. Nat Rev Rheumatol. 2020; 16: 239-246 Crossref PubMed Scopus (52) Google Scholar As one practical example, in the treatment of rheumatoid arthritis, the European Alliance of Associations for Rheumatology recommends to consider short-term glucocorticoids when initiating or changing conventional synthetic disease-modifying antirheumatic drugs, but then to taper and discontinue them as rapidly as is clinically feasible. The Glucocorticoid Toxicity Index-Metabolic Domains, an abridged version of the Glucocorticoid Toxicity Index: post-hoc analysis of data from the ADVOCATE trialThe GTI-MD correlates well with the full GTI and could be incorporated readily into routine clinic workflows without additional input from the clinician. Using the GTI-MD on the background of electronic medical records systems could help clinicians to monitor glucocorticoid toxicity longitudinally, with the goals of preventing the burden of chronic, treatment-related harms and reducing long-term costs to health systems. Full-Text PDF" @default.
• W4382045462 created "2023-06-27" @default.
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• W4382045462 date "2023-07-01" @default.
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• W4382045462 title "Getting better at quantifying the toxicity of glucocorticoids" @default.
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• W4382045462 doi "https://doi.org/10.1016/s2665-9913(23)00159-5" @default.
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