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- W4382045900 endingPage "110557" @default.
- W4382045900 startingPage "110557" @default.
- W4382045900 abstract "The CD24 protein is a heat-stable protein with a small core that undergoes extensive glycosylation. It is expressed on the surface of various normal cells, including lymphocytes, epithelial cells, and inflammatory cells. CD24 exerts its function by binding to different ligands. Numerous studies have demonstrated the close association of CD24 with tumor occurrence and progression. CD24 not only facilitates tumor cell proliferation, metastasis, and immune evasion but also plays a role in tumor initiation, thus, serving as a marker on the surface of cancer stem cells (CSCs). Additionally, CD24 induces drug resistance in various tumor cells following chemotherapy. To counteract the tumor-promoting effects of CD24, several treatment strategies targeting CD24 have been explored, such as the use of CD24 monoclonal antibodies (mAb) alone, the combination of CD24 and chemotoxic drugs, or the combination of these drugs with other targeted immunotherapeutic techniques. Regardless of the approach, targeting CD24 has demonstrated significant anti-tumor effects. Therefore, the present study focuses on anti-tumor therapy and provides a comprehensive review of the structure and fundamental physiological function of CD24 and its impact on tumor development, and suggests that targeting CD24 may represent an effective strategy for treating malignant tumors." @default.
- W4382045900 created "2023-06-27" @default.
- W4382045900 creator A5019342088 @default.
- W4382045900 creator A5033323312 @default.
- W4382045900 creator A5049922824 @default.
- W4382045900 creator A5050792667 @default.
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- W4382045900 creator A5065418938 @default.
- W4382045900 creator A5066738004 @default.
- W4382045900 creator A5085239567 @default.
- W4382045900 date "2023-08-01" @default.
- W4382045900 modified "2023-10-16" @default.
- W4382045900 title "CD24 blockade as a novel strategy for cancer treatment" @default.
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