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- W4382047657 abstract "Abstract We report a case of diffuse large B-cell lymphoma that progressed rapidly after androgen deprivation therapy for prostate cancer in a patient with a history of IgG4-related disease. Estrogen has been reported to be a possible cause of acute exacerbations of malignant lymphoma. However, to date, this has only been reported in mouse models, with no reports of clinical cases, and its clinical significance has not been clarified. This case report describes a 75-year-old man with prostate cancer who had IgG4-related disease in the background. Hormone therapy was initiated to treat prostate cancer, but he developed dyspnea and back pain. Computed tomography showed enlargement of bilateral renal hilar masses, swelling of the lymph nodes in the mediastinum, and soft masses in the spinal canal. The specimens obtained by Computed tomography-guided biopsy of the mediastinal mass led to the diagnosis of diffuse large B-cell lymphoma. Immunohistochemistry was positive for estrogen receptor β, which led us to suspect rapid progression of diffuse large B-cell lymphoma due to estrogen suppression by Gonadotropin-releasing hormone antagonists. Hormone therapy was discontinued, and the patient received R-CHOP therapy. Subsequently, the lymphoma masses shrunk markedly, and the patient obtained remission. This case is the first report of clinical significance regarding the crucial role of estrogen and ERβ in malignant lymphoma in a patient with IgG4-related disease. This case report aims to raise awareness of the need to carefully select treatment options for prostate cancer patients with IgG4-related disease or lymphoma." @default.
- W4382047657 created "2023-06-27" @default.
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- W4382047657 date "2023-06-26" @default.
- W4382047657 modified "2023-10-16" @default.
- W4382047657 title "Androgen deprivation therapy caused a drastic proliferation of B-cell lymphoma with IgG4-related disease in patients with prostate cancer: a case report" @default.
- W4382047657 doi "https://doi.org/10.21203/rs.3.rs-3077983/v1" @default.
- W4382047657 hasPublicationYear "2023" @default.
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