Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382049076> ?p ?o ?g. }
- W4382049076 abstract "Abstract The function of the smooth muscle cells lining the walls of systemic arteries and arterioles is to regulate the diameter of the vessels to control blood flow and blood pressure. Here, we describe an in-silico model, which we call the “Hernandez-Hernandez model”, of electrical and Ca 2+ signaling in arterial myocytes based on new experimental data indicating sex-specific differences in male and female arterial myocytes from resistance arteries. The model suggests the fundamental ionic mechanisms underlying membrane potential and intracellular Ca 2+ signaling during the development of myogenic tone in arterial blood vessels. Although experimental data suggest that K V 1.5 channel currents have similar amplitudes, kinetics, and voltage dependencies in male and female myocytes, simulations suggest that the K V 1.5 current is the dominant current regulating membrane potential in male myocytes. In female cells, which have larger K V 2.1 channel expression and longer time constants for activation than male myocytes, predictions from simulated female myocytes suggest that K V 2.1 plays a primary role in the control of membrane potential. Over the physiological range of membrane potentials, the gating of a small number of voltage-gated K + channels and L-type Ca 2+ channels are predicted to drive sex-specific differences in intracellular Ca 2+ and excitability. We also show that in an idealized computational model of a vessel, female arterial smooth muscle exhibits heightened sensitivity to commonly used Ca 2+ channel blockers compared to male. In summary, we present a new model framework to investigate the potential sex-specific impact of anti-hypertensive drugs." @default.
- W4382049076 created "2023-06-27" @default.
- W4382049076 creator A5006806888 @default.
- W4382049076 creator A5031553126 @default.
- W4382049076 creator A5035210033 @default.
- W4382049076 creator A5056514804 @default.
- W4382049076 creator A5071823741 @default.
- W4382049076 creator A5072287308 @default.
- W4382049076 creator A5080438512 @default.
- W4382049076 creator A5082049761 @default.
- W4382049076 creator A5083775247 @default.
- W4382049076 date "2023-06-26" @default.
- W4382049076 modified "2023-10-17" @default.
- W4382049076 title "A computational model predicts sex-specific responses to calcium channel blockers in mesenteric vascular smooth muscle" @default.
- W4382049076 cites W134363133 @default.
- W4382049076 cites W1579034755 @default.
- W4382049076 cites W1884656506 @default.
- W4382049076 cites W1938377867 @default.
- W4382049076 cites W1953284917 @default.
- W4382049076 cites W1965021019 @default.
- W4382049076 cites W1965052647 @default.
- W4382049076 cites W1965078214 @default.
- W4382049076 cites W1965139977 @default.
- W4382049076 cites W1965363502 @default.
- W4382049076 cites W1971788599 @default.
- W4382049076 cites W1972617290 @default.
- W4382049076 cites W1979075541 @default.
- W4382049076 cites W1982474507 @default.
- W4382049076 cites W1990233366 @default.
- W4382049076 cites W1991649249 @default.
- W4382049076 cites W1993119579 @default.
- W4382049076 cites W1996037906 @default.
- W4382049076 cites W1996502270 @default.
- W4382049076 cites W1999374220 @default.
- W4382049076 cites W2001256011 @default.
- W4382049076 cites W2004084338 @default.
- W4382049076 cites W2011028126 @default.
- W4382049076 cites W2014773670 @default.
- W4382049076 cites W2016326896 @default.
- W4382049076 cites W2020750779 @default.
- W4382049076 cites W2021022384 @default.
- W4382049076 cites W2021858120 @default.
- W4382049076 cites W2023541287 @default.
- W4382049076 cites W2025644841 @default.
- W4382049076 cites W2027111992 @default.
- W4382049076 cites W2029972291 @default.
- W4382049076 cites W2033433312 @default.
- W4382049076 cites W2036082842 @default.
- W4382049076 cites W2036145275 @default.
- W4382049076 cites W2039931031 @default.
- W4382049076 cites W2040800730 @default.
- W4382049076 cites W2050099786 @default.
- W4382049076 cites W2052439504 @default.
- W4382049076 cites W2063259765 @default.
- W4382049076 cites W2070664866 @default.
- W4382049076 cites W2071969879 @default.
- W4382049076 cites W2082326025 @default.
- W4382049076 cites W2083806469 @default.
- W4382049076 cites W2086666592 @default.
- W4382049076 cites W2086795250 @default.
- W4382049076 cites W2092434590 @default.
- W4382049076 cites W2099024685 @default.
- W4382049076 cites W2100199859 @default.
- W4382049076 cites W2106264616 @default.
- W4382049076 cites W2108745939 @default.
- W4382049076 cites W2110868985 @default.
- W4382049076 cites W2111450699 @default.
- W4382049076 cites W2115291646 @default.
- W4382049076 cites W2117597411 @default.
- W4382049076 cites W2117707422 @default.
- W4382049076 cites W2119127509 @default.
- W4382049076 cites W2122089569 @default.
- W4382049076 cites W2125632358 @default.
- W4382049076 cites W2130321115 @default.
- W4382049076 cites W2130675708 @default.
- W4382049076 cites W2132315098 @default.
- W4382049076 cites W2132561989 @default.
- W4382049076 cites W2137006279 @default.
- W4382049076 cites W2140574799 @default.
- W4382049076 cites W2149635665 @default.
- W4382049076 cites W2151675674 @default.
- W4382049076 cites W2152156058 @default.
- W4382049076 cites W2153212209 @default.
- W4382049076 cites W2155090730 @default.
- W4382049076 cites W2156600279 @default.
- W4382049076 cites W2160944315 @default.
- W4382049076 cites W2168142651 @default.
- W4382049076 cites W2171534955 @default.
- W4382049076 cites W2199746558 @default.
- W4382049076 cites W2270296605 @default.
- W4382049076 cites W2400010422 @default.
- W4382049076 cites W2580444287 @default.
- W4382049076 cites W2765267846 @default.
- W4382049076 cites W278274984 @default.
- W4382049076 cites W2943411338 @default.
- W4382049076 cites W2951031870 @default.
- W4382049076 cites W2956154393 @default.
- W4382049076 cites W2964422834 @default.
- W4382049076 cites W3005387122 @default.
- W4382049076 cites W3130490993 @default.