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- W4382049649 abstract "ABSTRACT The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here we identify the synapsin E-domain as an essential functional binding-partner of α-synuclein (α-syn). Synapsin E-domain allows α-syn functionality, binds to α-syn, and is necessary and sufficient for enabling effects of α-syn at the synapse. Together with previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters." @default.
- W4382049649 created "2023-06-27" @default.
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- W4382049649 date "2023-06-26" @default.
- W4382049649 modified "2023-09-23" @default.
- W4382049649 title "Synapsin E-domain is essential for α-synuclein function" @default.
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- W4382049649 doi "https://doi.org/10.1101/2023.06.24.546170" @default.
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