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- W4382049864 abstract "Autism spectrum disorder (ASD) is a neurodevelopmental disorder with various proposed environmental risk factors and a rapidly increasing prevalence. Mounting evidence suggests a potential role of vitamin D deficiency in ASD pathogenesis, though the causal mechanisms remain largely unknown. Here we investigate the impact of vitamin D on child neurodevelopment through an integrative network approach that combines metabolomic profiles, clinical traits, and neurodevelopmental data from a pediatric cohort. Our results show that vitamin D deficiency is associated with changes in the metabolic networks of tryptophan, linoleic, and fatty acid metabolism. These changes correlate with distinct ASD-related phenotypes, including delayed communication skills and respiratory dysfunctions. Additionally, our analysis suggests the kynurenine and serotonin sub-pathways may mediate the effect of vitamin D on early childhood communication development. Altogether, our findings provide metabolome-wide insights into the potential of vitamin D as a therapeutic option for ASD and other communication disorders." @default.
- W4382049864 created "2023-06-27" @default.
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- W4382049864 date "2023-06-26" @default.
- W4382049864 modified "2023-10-16" @default.
- W4382049864 title "The metabolic role of vitamin D in children’s neurodevelopment: a network study" @default.
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- W4382049864 doi "https://doi.org/10.1101/2023.06.23.546277" @default.
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