FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382049908> ?p ?o ?g. }

• W4382049908 abstract "Abstract Background: Early- and late-onset dementia with Lewy bodies (EO-DLB and LO-DLB) are similar in terms of core symptoms. However, LO-DLB presents with more amnestic deficits, while EO-DLB shows a rapid cognitive decline and more severe neuropsychiatric symptoms at onset. A contribution of neurotransmitter dysfunction was suggested but never explored, as a possible factor contributing to the reported clinical differences. By using FDG-PET brain metabolism imaging, we aimed to assess the differences between EO-DLB and LO-DLB regarding brain hypometabolism, related neurotransmitter functional topography, and metabolic connectivity. Methods: We included a total of 62 patients, 21 EO-DLB and 41 LO-DLB patients. Statistical parametric mapping (SPM) voxel-wise comparison with a validated dataset of healthy controls (N=112) provided brain hypometabolism patterns. A metabolic connectivity analysis assessed whole-brain and resting-state network (RSN) alterations. Furthermore, we used the JuSpace toolbox to evaluate the correlations between neurotransmitter pathways topography and brain hypometabolism. Results: Both EO- and LO-DLB groups showed typical bilateral occipito-parieto-frontal hypometabolism. Direct between-group comparison revealed a more severe hypometabolism in posterior cingulate cortex (PCC), precuneus, and occipital cortex for EO-DLB and a more severe hypometabolism in fronto-insular cortices for LO-DLB. Metabolic connectivity analysis showed significant reductions in posterior brain regions in both clinical groups compared to controls, as well as connectivity increases in the EO-DLB only. There were differences in the involvement of temporo-parietal and occipital pathological nodes. Specific RSN vulnerabilities were observed in the executive, default mode and limbic networks for EO-DLB and in the attentional network for LO-DLB. The spatial association analysis based on the metabolic differences in neurotransmission showed significant correlations with acetylcholine, gamma-aminobutyric acid (GABA), serotonin, dopamine maps, and hypometabolism in both EO and LO-DLB groups. Of note, the between-group comparison showed a higher correlation for the EO-DLB in the presynaptic serotonergic system. Overall, this indicates the biochemical involvement of metabolic impairment. Conclusions: This metabolic imaging study indicates similarities and differences between EO- and LO-DLB, both in terms of brain hypometabolism, across different neurotransmission networks, and altered connectivity, adding novel biological evidence to the DLB syndromes." @default.
• W4382049908 created "2023-06-27" @default.
• W4382049908 creator A5015703556 @default.
• W4382049908 creator A5020641788 @default.
• W4382049908 creator A5039017810 @default.
• W4382049908 creator A5068751115 @default.
• W4382049908 creator A5070024100 @default.
• W4382049908 creator A5085580106 @default.
• W4382049908 creator A5091579352 @default.
• W4382049908 date "2023-06-26" @default.
• W4382049908 modified "2023-09-24" @default.
• W4382049908 title "Mapping brain metabolism, connectivity and neurotransmitters topography in early and late onset dementia with Lewy bodies" @default.
• W4382049908 cites W1963925180 @default.
• W4382049908 cites W1969431952 @default.
• W4382049908 cites W1973705647 @default.
• W4382049908 cites W1975914990 @default.
• W4382049908 cites W1986724788 @default.
• W4382049908 cites W1999830133 @default.
• W4382049908 cites W2000259640 @default.
• W4382049908 cites W2022928962 @default.
• W4382049908 cites W2028529684 @default.
• W4382049908 cites W2042510318 @default.
• W4382049908 cites W2044356060 @default.
• W4382049908 cites W2057245667 @default.
• W4382049908 cites W2058046532 @default.
• W4382049908 cites W2064066094 @default.
• W4382049908 cites W2072579944 @default.
• W4382049908 cites W2073449985 @default.
• W4382049908 cites W2101219946 @default.
• W4382049908 cites W2102572922 @default.
• W4382049908 cites W2103717170 @default.
• W4382049908 cites W2116658855 @default.
• W4382049908 cites W2120786099 @default.
• W4382049908 cites W2125360348 @default.
• W4382049908 cites W2254886489 @default.
• W4382049908 cites W2461173142 @default.
• W4382049908 cites W2593585271 @default.
• W4382049908 cites W2603159238 @default.
• W4382049908 cites W2605629718 @default.
• W4382049908 cites W2623521763 @default.
• W4382049908 cites W2766851773 @default.
• W4382049908 cites W2924947794 @default.
• W4382049908 cites W2995668974 @default.
• W4382049908 cites W3006471518 @default.
• W4382049908 cites W4290643195 @default.
• W4382049908 doi "https://doi.org/10.21203/rs.3.rs-3083821/v1" @default.
• W4382049908 hasPublicationYear "2023" @default.
• W4382049908 type Work @default.
• W4382049908 citedByCount "0" @default.
• W4382049908 crossrefType "posted-content" @default.
• W4382049908 hasAuthorship W4382049908A5015703556 @default.
• W4382049908 hasAuthorship W4382049908A5020641788 @default.
• W4382049908 hasAuthorship W4382049908A5039017810 @default.
• W4382049908 hasAuthorship W4382049908A5068751115 @default.
• W4382049908 hasAuthorship W4382049908A5070024100 @default.
• W4382049908 hasAuthorship W4382049908A5085580106 @default.
• W4382049908 hasAuthorship W4382049908A5091579352 @default.
• W4382049908 hasBestOaLocation W43820499081 @default.
• W4382049908 hasConcept C126322002 @default.
• W4382049908 hasConcept C126838900 @default.
• W4382049908 hasConcept C141516989 @default.
• W4382049908 hasConcept C143409427 @default.
• W4382049908 hasConcept C15744967 @default.
• W4382049908 hasConcept C164705383 @default.
• W4382049908 hasConcept C169760540 @default.
• W4382049908 hasConcept C169900460 @default.
• W4382049908 hasConcept C2777348757 @default.
• W4382049908 hasConcept C2778548049 @default.
• W4382049908 hasConcept C2778733324 @default.
• W4382049908 hasConcept C2779134260 @default.
• W4382049908 hasConcept C2779483572 @default.
• W4382049908 hasConcept C2781441883 @default.
• W4382049908 hasConcept C2993858690 @default.
• W4382049908 hasConcept C3018011982 @default.
• W4382049908 hasConcept C39313694 @default.
• W4382049908 hasConcept C66324658 @default.
• W4382049908 hasConcept C71924100 @default.
• W4382049908 hasConceptScore W4382049908C126322002 @default.
• W4382049908 hasConceptScore W4382049908C126838900 @default.
• W4382049908 hasConceptScore W4382049908C141516989 @default.
• W4382049908 hasConceptScore W4382049908C143409427 @default.
• W4382049908 hasConceptScore W4382049908C15744967 @default.
• W4382049908 hasConceptScore W4382049908C164705383 @default.
• W4382049908 hasConceptScore W4382049908C169760540 @default.
• W4382049908 hasConceptScore W4382049908C169900460 @default.
• W4382049908 hasConceptScore W4382049908C2777348757 @default.
• W4382049908 hasConceptScore W4382049908C2778548049 @default.
• W4382049908 hasConceptScore W4382049908C2778733324 @default.
• W4382049908 hasConceptScore W4382049908C2779134260 @default.
• W4382049908 hasConceptScore W4382049908C2779483572 @default.
• W4382049908 hasConceptScore W4382049908C2781441883 @default.
• W4382049908 hasConceptScore W4382049908C2993858690 @default.
• W4382049908 hasConceptScore W4382049908C3018011982 @default.
• W4382049908 hasConceptScore W4382049908C39313694 @default.
• W4382049908 hasConceptScore W4382049908C66324658 @default.
• W4382049908 hasConceptScore W4382049908C71924100 @default.
• W4382049908 hasLocation W43820499081 @default.
• W4382049908 hasOpenAccess W4382049908 @default.
• W4382049908 hasPrimaryLocation W43820499081 @default.
• W4382049908 hasRelatedWork W1983299337 @default.

• next