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- W4382051233 startingPage "105296" @default.
- W4382051233 abstract "A fundamental shift in neuroscience suggests bidirectional interaction of gut microbiota with the healthy and dysfunctional brain. This microbiota-gut-brain axis has mainly been investigated in stress-related psychopathology (e.g. depression, anxiety). The hippocampus, a key structure in both the healthy brain and psychopathologies, is implicated by work in rodents that suggests gut microbiota substantially impact hippocampal-dependent learning and memory. However, understanding microbiota-hippocampus mechanisms in health and disease, and translation to humans, is hampered by the absence of a coherent evaluative approach. We review the current knowledge regarding four main gut microbiota-hippocampus routes in rodents: through the vagus nerve; via the hypothalamus-pituitary-adrenal-axis; by metabolism of neuroactive substances; and through modulation of host inflammation. Next, we suggest an approach including testing (biomarkers of) the four routes as a function of the influence of gut microbiota (composition) on hippocampal-dependent (dys)functioning. We argue that such an approach is necessary to proceed from the current state of preclinical research to beneficial application in humans to optimise microbiota-based strategies to treat and enhance hippocampal-dependent memory (dys)functions." @default.
- W4382051233 created "2023-06-27" @default.
- W4382051233 creator A5039030658 @default.
- W4382051233 creator A5063130835 @default.
- W4382051233 date "2023-09-01" @default.
- W4382051233 modified "2023-09-30" @default.
- W4382051233 title "The microbiota-gut-brain axis in hippocampus-dependent learning and memory: current state and future challenges" @default.
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