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• W4382051409 abstract "A growing body of evidence suggests that immune-related genes play pivotal roles in the pathophysiology of depression. In the present study, we investigated a plausible connection between gene expression, DNA methylation, and brain structural changes in the pathophysiology of depression using a combined approach of murine and human studies. We ranked the immobility behaviors of 30 outbred Crl:CD1 (ICR) mice in the forced swim test (FST) and harvested their prefrontal cortices for RNA sequencing. Of the 24,532 analyzed genes, 141 showed significant correlations with FST immobility time, as determined through linear regression analysis with p≤0.01. The identified genes were mostly involved in immune responses, especially interferon signaling pathways. Moreover, induction of virus-like neuroinflammation in the brains of two separate mouse cohorts (n=30 each) using intracerebroventricular polyinosinic:polycytidylic acid injection resulted in increased immobility during FST and similar expression of top immobility-correlated genes. In human blood samples, candidate gene (top 5%) expression profiling using DNA methylation analysis found the interferon-related USP18 (cg25484698, p=7.04 × 10−11, Δβ=1.57 × 10–2; cg02518889, p=2.92 × 10−3, Δβ=−8.20 × 10–3) and IFI44 (cg07107453, p=3.76 × 10–3, Δβ=−4.94 × 10–3) genes to be differentially methylated between patients with major depressive disorder (n=350) and healthy controls (n=161). Furthermore, cortical thickness analyses using T1-weighted images revealed that the DNA methylation scores for USP18 were negatively correlated with the thicknesses of several cortical regions, including the prefrontal cortex. Our results reveal the important role of the interferon pathway in depression and suggest USP18 as a potential candidate target. The results of the correlation analysis between transcriptomic data and animal behavior carried out in this study provide insights that could enhance our understanding of depression in humans." @default.
• W4382051409 created "2023-06-27" @default.
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• W4382051409 date "2023-10-01" @default.
• W4382051409 modified "2023-09-24" @default.
• W4382051409 title "Correlation between immune-related genes and depression-like features in an animal model and in humans" @default.
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• W4382051409 doi "https://doi.org/10.1016/j.bbi.2023.06.017" @default.
• W4382051409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37379963" @default.
• W4382051409 hasPublicationYear "2023" @default.
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