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• W4382051907 abstract "We investigated the impact of dimethyl fumarate (DMF), an oral therapy for relapsing multiple sclerosis (MS), on blood microRNA (miRNA) signatures and neurofilament light (NFL) levels. DMF normalized miR-660-5p and modulated various miRNAs associated with the NF-kB pathway. These alterations reached a peak 4-7 months after treatment. Notably, particular miRNAs correlated with high or low NFL levels, implying their potential role as markers of treatment efficacy. Our findings broaden the understanding of DMF's immunomodulatory effects and may aid in predicting treatment responses." @default.
• W4382051907 created "2023-06-27" @default.
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• W4382051907 date "2023-08-01" @default.
• W4382051907 modified "2023-09-26" @default.
• W4382051907 title "Whole blood miRNAs in relapsing MS patients treated with dimethyl fumarate in the phase 4 TREMEND trial" @default.
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• W4382051907 doi "https://doi.org/10.1016/j.jneuroim.2023.578145" @default.
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