FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382052014> ?p ?o ?g. }

• W4382052014 endingPage "155642" @default.
• W4382052014 startingPage "155642" @default.
• W4382052014 abstract "Background The prevalence of nonalcoholic fatty liver disease (NAFLD) is high among subjects with type 2 diabetes (T2D). However, the prevalence and outcomes of NAFLD among individuals with pre-diabetes (Pre D) and metabolically healthy and metabolically unhealthy individuals without T2D are not known. Our aim was to assess prevalence and mortality of NAFLD among these four groups. Methods The Third National Health and Nutrition Examination Survey (NHANES) III (1988–1994) with mortality data (follow up to 2019) via linkage to the National Death Index was utilized. NAFLD was defined by ultrasound and absence of other liver diseases and excess alcohol use. Pre-D was defined as fasting plasma glucose values of 100–125 mg/dL and/or HbA1c level between 5.7 %–6.4 % in the absence of established diagnosis of T2D. Metabolically healthy (MH) was defined if all of the following criteria were absent: waist circumference of ≥102 cm (men) or ≥ 88 cm (women) or BMI of ≥30; blood pressure (BP) ≥ 130/85 mmHg or using BP-lowering medication; triglyceride level ≥ 150 mg/dL or using lipid-lowering medication; lipoprotein cholesterol level of <40 mg/dL (men) or < 50 mg/dL (women); homeostasis model assessment of insulin resistance (HOMA-IR) score ≥ 2.5; C-reactive protein (CRP) level of >2 mg/L; Pre-D and T2D. Metabolically unhealthy (MU) individuals were defined as the presence of any component of metabolic syndrome but not having Pre-D and T2D. Competing risk analyses of cause-specific mortality were performed. Findings 11,231 adults (20-74y) were included: mean age 43.4 years; 43.9 % male; 75.4 % white, 10.8 % Black, and 5.4 % Mexican American, 18.9 % NAFLD, 7.8 % T2D; 24.7 % Pre D; 44.3 % MU; and 23.3 % in MH individuals. In multivariable adjusted logistic model, as compared to MH individuals, the highest risk of having NAFLD were in T2D individuals (Odd Ratio [OR] = 10.88 [95 % confidence interval: 7.33–16.16]), followed by Pre-D (OR = 4.19 [3.02–5.81]), and MU (OR = 3.36 [2.39–4.71]). During a median follow up of 26.7 years (21.2–28.7 years), 3982 died. NAFLD subjects had significantly higher age-adjusted mortality than non-NAFLD (32.7 % vs. 28.7 %, p < .001). Among subjects with NAFLD, the highest age-standardized cumulative mortality was observed among those with T2D (41.3 %), followed by with Pre-D (35.1 %), MU subjects (30.0 %), and MH subjects (21.9 %) (pairwise p-values<.04 vs. ND with MH). Multivariable adjusted cox models showed that NAFLD with T2D had a higher risk of all-causes and cardiac-specific deaths (Hazard Ratio [HR] = 4.71 [2.23–9.96] and HR = 20.01 [3.00–133.61]), followed by NAFLD with Pre-D (HR = 2.91 [1.41–6.02] and HR = 10.35 [1.57–68.08]) and metabolically unhealthy NAFLD (HR = 2.59 [1.26–5.33] and HR = 6.74 [0.99–46.03]) compared to metabolically healthy NAFLD. In addition to older age, independent predictors of mortality among NAFLD with T2D included high CRP, CVD, CKD, high FIB-4, and active smoking. Similarly, among NAFLD with Pre D, high CRP, CKD, CVD, hypertension, and active smoking were associated with mortality. Finally, CVD and active smoking were predictors of mortality among metabolically unhealthy NAFLD, and active smoking was the only mortality risk among metabolically healthy NAFLD subjects. Interpretation Metabolic abnormality impacts both prevalence and outcomes of subjects with NAFLD." @default.
• W4382052014 created "2023-06-27" @default.
• W4382052014 creator A5021269346 @default.
• W4382052014 creator A5042255258 @default.
• W4382052014 creator A5053950885 @default.
• W4382052014 creator A5080386622 @default.
• W4382052014 creator A5084895513 @default.
• W4382052014 creator A5086957117 @default.
• W4382052014 creator A5092266269 @default.
• W4382052014 creator A5092266270 @default.
• W4382052014 date "2023-09-01" @default.
• W4382052014 modified "2023-10-12" @default.
• W4382052014 title "Nonalcoholic fatty liver disease (NAFLD) and associated mortality in individuals with type 2 diabetes, pre-diabetes, metabolically unhealthy, and metabolically healthy individuals in the United States" @default.
• W4382052014 cites W1975701178 @default.
• W4382052014 cites W2063437798 @default.
• W4382052014 cites W2080050561 @default.
• W4382052014 cites W2093935755 @default.
• W4382052014 cites W2103135709 @default.
• W4382052014 cites W2126285374 @default.
• W4382052014 cites W2136057321 @default.
• W4382052014 cites W2162382402 @default.
• W4382052014 cites W2204688218 @default.
• W4382052014 cites W2580009538 @default.
• W4382052014 cites W2734724639 @default.
• W4382052014 cites W2759997926 @default.
• W4382052014 cites W2768762167 @default.
• W4382052014 cites W2794816422 @default.
• W4382052014 cites W2896097004 @default.
• W4382052014 cites W2901363517 @default.
• W4382052014 cites W2945583517 @default.
• W4382052014 cites W2955615964 @default.
• W4382052014 cites W2965513750 @default.
• W4382052014 cites W2966701995 @default.
• W4382052014 cites W2980303595 @default.
• W4382052014 cites W2990737007 @default.
• W4382052014 cites W2998643329 @default.
• W4382052014 cites W3000140653 @default.
• W4382052014 cites W3001874034 @default.
• W4382052014 cites W3003817584 @default.
• W4382052014 cites W3006028518 @default.
• W4382052014 cites W3020512321 @default.
• W4382052014 cites W3127981559 @default.
• W4382052014 cites W3136175338 @default.
• W4382052014 cites W3143409077 @default.
• W4382052014 cites W3160407865 @default.
• W4382052014 cites W3181107254 @default.
• W4382052014 cites W3196974099 @default.
• W4382052014 cites W3199799519 @default.
• W4382052014 cites W3201257031 @default.
• W4382052014 cites W3204212615 @default.
• W4382052014 cites W3206948891 @default.
• W4382052014 cites W4214645246 @default.
• W4382052014 cites W4220821646 @default.
• W4382052014 cites W4226161394 @default.
• W4382052014 cites W4280552835 @default.
• W4382052014 cites W4280599356 @default.
• W4382052014 cites W4283804489 @default.
• W4382052014 cites W4288010199 @default.
• W4382052014 cites W4291019074 @default.
• W4382052014 cites W4294085549 @default.
• W4382052014 cites W4297243229 @default.
• W4382052014 cites W4306867780 @default.
• W4382052014 cites W4311239397 @default.
• W4382052014 cites W4315619045 @default.
• W4382052014 doi "https://doi.org/10.1016/j.metabol.2023.155642" @default.
• W4382052014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37380016" @default.
• W4382052014 hasPublicationYear "2023" @default.
• W4382052014 type Work @default.
• W4382052014 citedByCount "1" @default.
• W4382052014 countsByYear W43820520142023 @default.
• W4382052014 crossrefType "journal-article" @default.
• W4382052014 hasAuthorship W4382052014A5021269346 @default.
• W4382052014 hasAuthorship W4382052014A5042255258 @default.
• W4382052014 hasAuthorship W4382052014A5053950885 @default.
• W4382052014 hasAuthorship W4382052014A5080386622 @default.
• W4382052014 hasAuthorship W4382052014A5084895513 @default.
• W4382052014 hasAuthorship W4382052014A5086957117 @default.
• W4382052014 hasAuthorship W4382052014A5092266269 @default.
• W4382052014 hasAuthorship W4382052014A5092266270 @default.
• W4382052014 hasConcept C126322002 @default.
• W4382052014 hasConcept C134018914 @default.
• W4382052014 hasConcept C2776193436 @default.
• W4382052014 hasConcept C2776954865 @default.
• W4382052014 hasConcept C2777180221 @default.
• W4382052014 hasConcept C2777391703 @default.
• W4382052014 hasConcept C2778163477 @default.
• W4382052014 hasConcept C2778535154 @default.
• W4382052014 hasConcept C2778772119 @default.
• W4382052014 hasConcept C2778913445 @default.
• W4382052014 hasConcept C2779134260 @default.
• W4382052014 hasConcept C2779874844 @default.
• W4382052014 hasConcept C2780221984 @default.
• W4382052014 hasConcept C2780578515 @default.
• W4382052014 hasConcept C2908647359 @default.
• W4382052014 hasConcept C42407357 @default.
• W4382052014 hasConcept C555293320 @default.
• W4382052014 hasConcept C71924100 @default.
• W4382052014 hasConcept C90924648 @default.

• next