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- W4382055191 endingPage "1560" @default.
- W4382055191 startingPage "1549" @default.
- W4382055191 abstract "Abstract To explore favourable niches while avoiding threats, many bacteria use a chemotaxis navigation system. Despite decades of studies on chemotaxis, most signals and sensory proteins are still unknown. Many bacterial species release d -amino acids to the environment; however, their function remains largely unrecognized. Here we reveal that d -arginine and d -lysine are chemotactic repellent signals for the cholera pathogen Vibrio cholerae . These d -amino acids are sensed by a single chemoreceptor MCP DRK co-transcribed with the racemase enzyme that synthesizes them under the control of the stress-response sigma factor RpoS. Structural characterization of this chemoreceptor bound to either d -arginine or d -lysine allowed us to pinpoint the residues defining its specificity. Interestingly, the specificity for these d -amino acids appears to be restricted to those MCP DRK orthologues transcriptionally linked to the racemase. Our results suggest that d -amino acids can shape the biodiversity and structure of complex microbial communities under adverse conditions." @default.
- W4382055191 created "2023-06-27" @default.
- W4382055191 creator A5006663720 @default.
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- W4382055191 date "2023-06-26" @default.
- W4382055191 modified "2023-10-17" @default.
- W4382055191 title "d-amino acids signal a stress-dependent run-away response in Vibrio cholerae" @default.
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- W4382055191 doi "https://doi.org/10.1038/s41564-023-01419-6" @default.
- W4382055191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37365341" @default.