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- W4382066018 startingPage "1436" @default.
- W4382066018 abstract "Brown adipose tissue (BAT), an important regulator of thermogenic and metabolic processes, is considered a promising target to combat metabolic disorders. The neurotransmitter and hormone serotonin (5HT) is a major modulator of energy homeostasis, with its central and peripheral pools acting in opposing ways. To better understand how individual variations in 5HT homeostasis influence the thermogenic functionality of BAT, we used a rat model consisting of two sublines with constitutively increased (high-5HT) or decreased (low-5HT) whole-body 5HT tone, developed by selective breeding for platelet 5HT parameters. We have shown that animals with constitutively low 5HT activity maintained at a standard housing temperature (22 °C) have greater interscapular BAT (iBAT) mass and higher iBAT metabolic activity (as evidenced by measurements of iBAT temperature and glucose uptake), accompanied by increased iBAT mRNA expression of key thermogenic genes, compared to animals with high 5HT tone. In response to further thermogenic challenges—intermittent cold exposure or treatment with a β3-adrenergic agonist—5HT sublines show several functional and molecular differences linking constitutively low endogenous 5HT tone to higher BAT activity/capacity. Overall, the results support a role of 5-HT in the control of BAT thermogenesis They also suggest that individuals with lower 5HT activity may be more sensitive to β3-adrenergic drugs." @default.
- W4382066018 created "2023-06-27" @default.
- W4382066018 creator A5007012363 @default.
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- W4382066018 creator A5075183553 @default.
- W4382066018 date "2023-06-25" @default.
- W4382066018 modified "2023-09-26" @default.
- W4382066018 title "Constitutive Serotonin Tone as a Modulator of Brown Adipose Tissue Thermogenesis: A Rat Study" @default.
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- W4382066018 cites W2031551101 @default.
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- W4382066018 cites W2980163224 @default.
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- W4382066018 doi "https://doi.org/10.3390/life13071436" @default.
- W4382066018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37511811" @default.
- W4382066018 hasPublicationYear "2023" @default.
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