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- W4382072512 abstract "As resistance to current breast cancer treatments continues to rise, researching new treatments is critical. This thesis investigated the role of modifications to a cancer relevant protein, cyclin D1, in breast cancer cell growth. Interestingly, it was discovered that cyclin D1 was modified by both SUMOylation and UFMylation. Specifically, disruption to the SUMOylation modification destabilised cyclin D1, causing the protein to be degraded by the cancer cell. Disruption to the UFMylation modification also affected protein stability. These novel findings indicate a potential for treatments which reduce the amount of cyclin D1 and lead to a reduction in breast cancer growth." @default.
- W4382072512 created "2023-06-27" @default.
- W4382072512 creator A5048866945 @default.
- W4382072512 date "2023-06-26" @default.
- W4382072512 modified "2023-09-29" @default.
- W4382072512 title "Investigating post-translational modification of cyclin D1 in breast cancer" @default.
- W4382072512 doi "https://doi.org/10.5204/thesis.eprints.240785" @default.
- W4382072512 hasPublicationYear "2023" @default.
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