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- W4382073712 abstract ": Borderline resectable pancreatic cancer (BRPC) has emerged as a unique entity among the spectrum of pancreatic cancer adenocarcinoma. BRPC is defined as pancreatic cancer having contact with vascular structures, unfavorable tumor biology including subclinical metastatic disease, or in a patient with poor performance status. The standard of care in the management of pancreatic cancer has evolved over time from adjuvant therapy to neoadjuvant therapy (NAT) approaches, which has allowed for a more tailored approach to the management of patients with BRPC, thereby improving outcomes for these patients. There are several potential benefits of NAT including treatment of micrometastasis, appropriate patient selection for surgery, and reduction in positive margin resection, which is associated with negative outcomes. Conventional chemoradiation and stereotactic body radiation therapy (SBRT) are the most common methods of delivering neoadjuvant radiation, and both appear to improve margin negative resection rates, and pathologic response rates for patients. Improvements in systemic control have improved control of systemic disease and created an evolving role for radiation therapy in an effort to improve local tumor control and bridge patients to the ultimate goal of a successful surgery. Technological advances have additionally created a number of radiation options for patients with pancreatic cancer including adaptive therapy with magnetic resonance imaging (MRI) or computed tomography (CT) guidance and intraoperative radiation therapy. The role of radiation in BRPC remains vital and the many choices in treatment strategy continue to evolve in the era of multidisciplinary care." @default.
- W4382073712 created "2023-06-27" @default.
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- W4382073712 date "2023-06-01" @default.
- W4382073712 modified "2023-09-24" @default.
- W4382073712 title "Borderline resectable pancreatic cancer: a review of recent radiation therapy literature and clinical practice" @default.
- W4382073712 doi "https://doi.org/10.21037/dmr-22-69" @default.
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