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• W4382132938 abstract "IntroductionThe complete systemic deregulated biological network in peritoneal dialysis (PD) patients is still only partially defined. High-throughput/omics techniques may offer the possibility to analyze the main biological fingerprints associated with this clinical condition.MethodsWe applied an innovative bioinformatic analysis of gene-expression microarray data (mainly based on support vector machine learning) to compare the transcriptomic profile of peripheral blood mononuclear cells (PBMCs) of healthy subjects (HS), chronic kidney disease (CKD) patients, and PD patients divided into a microarray group (5 HS, 9 CKD and 10 PD) and a validation group (10 HS, 15 CKD and 15 PD). Classical well-standardized biomolecular approaches (western blotting and flow cytometry) were used to validate the transcriptomic results.ResultsBioinformatics revealed a distinctive PBMCs transcriptomic profiling for PD versus CKD and HS (n: 419 genes). Transcripts encoding for key elements of the autophagic pathway were significantly up-regulated in PD, and the autophagy-related 5 (ATG5) reached the top level of discrimination (-Log10 p.value=11.3, VIP score=4.8, SVM rank:1). Protein levels of ATG5 and microtubule associated protein 1 light chain 3 beta (LC3B), an important constituent of the autophagosome, validated microarray results. Additionally, the incubation of PBMCs of HS with serum of PD patients upregulated both proteins. Autophagy in PBMCs from PD patients was attenuated by N-acetyl-cysteine or Resatorvid treatment.ConclusionsOur data demonstrated, for the first time, that the autophagy pathway is activated in immune-cells of PD patients and this may represent a novel therapeutic target." @default.
• W4382132938 created "2023-06-27" @default.
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• W4382132938 date "2023-09-01" @default.
• W4382132938 modified "2023-09-25" @default.
• W4382132938 title "Autophagy Activation in Peripheral Blood Mononuclear Cells of Peritoneal Dialysis Patients" @default.
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• W4382132938 doi "https://doi.org/10.1016/j.ekir.2023.06.017" @default.
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• W4382132938 hasPublicationYear "2023" @default.
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