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- W4382133935 endingPage "1801" @default.
- W4382133935 startingPage "1801" @default.
- W4382133935 abstract "Sepsis is associated with dysregulated cortisol secretion, leading to abnormal levels of cortisol in the blood. In the early stages of the condition, cortisol levels are typically elevated due to increased secretion from the adrenal glands. However, as the disease progresses, cortisol levels may decline due to impaired adrenal function, leading to relative adrenal insufficiency. The latter is thought to be caused by a combination of factors, including impaired adrenal function, decreased production of corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) by the hypothalamus and pituitary gland, and increased breakdown of cortisol. The dysregulation of cortisol secretion in sepsis is thought to contribute to the pathophysiology of the disease by impairing the body's ability to mount an appropriate inflammatory response. Given the dysregulation of cortisol secretion and corticosteroid receptors in sepsis, there has been considerable interest in the use of steroids as a treatment. However, clinical trials have yielded mixed results and corticosteroid use in sepsis remains controversial. In this review, we will discuss the changes in cortisol secretion and corticosteroid receptors in critically ill patients with sepsis/septic shock. We will also make special note of COVID-19 patients, who presented a recent challenge for ICU management, and explore the scope for corticosteroid administration in both COVID-19 and non-COVID-19 septic patients." @default.
- W4382133935 created "2023-06-27" @default.
- W4382133935 creator A5010972418 @default.
- W4382133935 creator A5020990786 @default.
- W4382133935 creator A5024540124 @default.
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- W4382133935 creator A5060168513 @default.
- W4382133935 creator A5064676747 @default.
- W4382133935 creator A5073129873 @default.
- W4382133935 date "2023-06-23" @default.
- W4382133935 modified "2023-09-26" @default.
- W4382133935 title "Changes in Cortisol Secretion and Corticosteroid Receptors in COVID-19 and Non COVID-19 Critically Ill Patients with Sepsis/Septic Shock and Scope for Treatment" @default.
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