Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382135087> ?p ?o ?g. }
- W4382135087 endingPage "905" @default.
- W4382135087 startingPage "905" @default.
- W4382135087 abstract "Alzheimer's disease (AD) is the most common cause of age-related neurodegeneration and cognitive decline. AD more commonly occurs in females than in males, so it is necessary to consider new treatments specifically targeting this population. The present study investigated the protective effects of Begacestat (γ-secretase inhibitor-953, GSI-953) and bone marrow-derived mesenchymal stem cells (BM-MSCs) during pregnancy on cognitive impairment in rat dams and neurodegeneration in offspring caused by the intracerebroventricular injection of Aβ 25-35 before pregnancy. The performances of dams injected with amyloid-β 25-35 (Aβ 25-35) during behavioral tests were significantly impaired. The offspring of Aβ 25-35-injected dams treated with BM-MSCs or GSI-953 showed a dramatically reduced number and size of activated microglial cells, enhancement in the processes length, and a decrease in the proinflammatory cytokine levels. Additionally, BM-MSC or GSI-953 therapy reduced Aβ 25-35-induced increases in tau phosphorylation and amyloid precursor protein levels in the neonates' hippocampus and elevated the lower levels of glycogen synthase kinase-3 and brain-derived neurotrophic factor; moreover, reversed Aβ 25-35-induced alterations in gene expression in the neonatal hippocampus. Finally, the treatments with BM-MSC or GSI-953 are globally beneficial against Aβ 25-35-induced brain alterations, particularly by suppressing neural inflammation, inhibiting microglial cell activation, restoring developmental plasticity, and increasing neurotrophic signaling." @default.
- W4382135087 created "2023-06-27" @default.
- W4382135087 creator A5007894459 @default.
- W4382135087 creator A5027814734 @default.
- W4382135087 creator A5053218128 @default.
- W4382135087 creator A5054370050 @default.
- W4382135087 creator A5074230436 @default.
- W4382135087 creator A5079872160 @default.
- W4382135087 creator A5084090396 @default.
- W4382135087 date "2023-06-25" @default.
- W4382135087 modified "2023-09-27" @default.
- W4382135087 title "Mesenchymal Stem Cells and Begacestat Mitigate Amyloid-β 25–35-Induced Cognitive Decline in Rat Dams and Hippocampal Deteriorations in Offspring" @default.
- W4382135087 cites W1476313724 @default.
- W4382135087 cites W1493382393 @default.
- W4382135087 cites W1961680179 @default.
- W4382135087 cites W1963597847 @default.
- W4382135087 cites W1970368333 @default.
- W4382135087 cites W1970865563 @default.
- W4382135087 cites W1972886222 @default.
- W4382135087 cites W1976773921 @default.
- W4382135087 cites W1984720732 @default.
- W4382135087 cites W1989654750 @default.
- W4382135087 cites W1991856249 @default.
- W4382135087 cites W2000209446 @default.
- W4382135087 cites W2004980098 @default.
- W4382135087 cites W2011114363 @default.
- W4382135087 cites W2012482368 @default.
- W4382135087 cites W2030898494 @default.
- W4382135087 cites W2043972048 @default.
- W4382135087 cites W2056962185 @default.
- W4382135087 cites W2071150630 @default.
- W4382135087 cites W2083103946 @default.
- W4382135087 cites W2092689214 @default.
- W4382135087 cites W2103056622 @default.
- W4382135087 cites W2107318881 @default.
- W4382135087 cites W2118951125 @default.
- W4382135087 cites W2122320288 @default.
- W4382135087 cites W2128141190 @default.
- W4382135087 cites W2131252939 @default.
- W4382135087 cites W2133962760 @default.
- W4382135087 cites W2137876368 @default.
- W4382135087 cites W2162798214 @default.
- W4382135087 cites W2170589477 @default.
- W4382135087 cites W2171250577 @default.
- W4382135087 cites W2237724900 @default.
- W4382135087 cites W2261842513 @default.
- W4382135087 cites W2300232175 @default.
- W4382135087 cites W2314634699 @default.
- W4382135087 cites W2464278358 @default.
- W4382135087 cites W2553491861 @default.
- W4382135087 cites W2581435615 @default.
- W4382135087 cites W2592995462 @default.
- W4382135087 cites W2625182166 @default.
- W4382135087 cites W2765603538 @default.
- W4382135087 cites W2911551407 @default.
- W4382135087 cites W2936271675 @default.
- W4382135087 cites W2941198005 @default.
- W4382135087 cites W2950249001 @default.
- W4382135087 cites W2964627277 @default.
- W4382135087 cites W2982115290 @default.
- W4382135087 cites W2992999384 @default.
- W4382135087 cites W3007333794 @default.
- W4382135087 cites W3015437269 @default.
- W4382135087 cites W3020009149 @default.
- W4382135087 cites W3031902590 @default.
- W4382135087 cites W3045897262 @default.
- W4382135087 cites W3080655225 @default.
- W4382135087 cites W3081099132 @default.
- W4382135087 cites W3093262344 @default.
- W4382135087 cites W3094514421 @default.
- W4382135087 cites W3123365422 @default.
- W4382135087 cites W3128023729 @default.
- W4382135087 cites W3135307596 @default.
- W4382135087 cites W3136399731 @default.
- W4382135087 cites W3137286199 @default.
- W4382135087 cites W3165328815 @default.
- W4382135087 cites W3201072771 @default.
- W4382135087 cites W3211798518 @default.
- W4382135087 cites W4206066638 @default.
- W4382135087 cites W4210328173 @default.
- W4382135087 cites W4210853061 @default.
- W4382135087 cites W4211139529 @default.
- W4382135087 cites W4214950145 @default.
- W4382135087 cites W4245465399 @default.
- W4382135087 cites W4247759744 @default.
- W4382135087 cites W4256562641 @default.
- W4382135087 cites W4313259873 @default.
- W4382135087 cites W4378192456 @default.
- W4382135087 cites W4380078428 @default.
- W4382135087 doi "https://doi.org/10.3390/biology12070905" @default.
- W4382135087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37508337" @default.
- W4382135087 hasPublicationYear "2023" @default.
- W4382135087 type Work @default.
- W4382135087 citedByCount "0" @default.
- W4382135087 crossrefType "journal-article" @default.
- W4382135087 hasAuthorship W4382135087A5007894459 @default.
- W4382135087 hasAuthorship W4382135087A5027814734 @default.
- W4382135087 hasAuthorship W4382135087A5053218128 @default.