Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382136044> ?p ?o ?g. }
- W4382136044 endingPage "4950" @default.
- W4382136044 startingPage "4950" @default.
- W4382136044 abstract "Nanoparticles (NPs), due to their size, have a key position in nanotechnology as a spectrum of solutions in medicine. NPs improve the ability of active substances to penetrate various routes: transdermal, but also digestive (active endocytosis), respiratory and injection. Chitosan, an N-deacetylated derivative of chitin, is a natural biodegradable cationic polymer with antioxidant, anti-inflammatory and antimicrobial properties. Cross-linked chitosan is an excellent matrix for the production of nanoparticles containing active substances, e.g., the Ginkgo biloba extract (GBE). Chitosan nanoparticles with the Ginkgo biloba extract (GBE) were obtained by ion gelation using TPP as a cross-linking agent. The obtained product was characterized in terms of morphology and size based on SEM and Zeta Sizer analyses as well as an effective encapsulation of GBE in nanoparticles—FTIR-ATR and UV-Vis analyses. The kinetics of release of the active substance in water and physiological saline were checked. Biological studies were carried out on normal and cancer cell lines to check the cytotoxic effect of GBE, chitosan nanoparticles and a combination of the chitosan nanoparticles with GBE. The obtained nanoparticles contained and released GBE encapsulated in research media. Pure NPs, GBE and a combination of NPs and the extract showed cytotoxicity against tumor cells, with no cytotoxicity against the physiological cell line." @default.
- W4382136044 created "2023-06-27" @default.
- W4382136044 creator A5004943203 @default.
- W4382136044 creator A5029541493 @default.
- W4382136044 creator A5062647358 @default.
- W4382136044 creator A5066651403 @default.
- W4382136044 creator A5067717800 @default.
- W4382136044 creator A5086096052 @default.
- W4382136044 creator A5088879726 @default.
- W4382136044 date "2023-06-23" @default.
- W4382136044 modified "2023-09-30" @default.
- W4382136044 title "Chitosan Nanoparticles-Preparation, Characterization and Their Combination with Ginkgo biloba Extract in Preliminary In Vitro Studies" @default.
- W4382136044 cites W1169841467 @default.
- W4382136044 cites W144422475 @default.
- W4382136044 cites W1564806321 @default.
- W4382136044 cites W1846505747 @default.
- W4382136044 cites W1981215463 @default.
- W4382136044 cites W1981636071 @default.
- W4382136044 cites W1982668610 @default.
- W4382136044 cites W1984942385 @default.
- W4382136044 cites W1987913373 @default.
- W4382136044 cites W2005713333 @default.
- W4382136044 cites W2014620175 @default.
- W4382136044 cites W2016149909 @default.
- W4382136044 cites W2023283179 @default.
- W4382136044 cites W2023657255 @default.
- W4382136044 cites W2044984546 @default.
- W4382136044 cites W2050677222 @default.
- W4382136044 cites W2051869030 @default.
- W4382136044 cites W2055452846 @default.
- W4382136044 cites W2057437898 @default.
- W4382136044 cites W2058454186 @default.
- W4382136044 cites W2105071660 @default.
- W4382136044 cites W2105298252 @default.
- W4382136044 cites W2106169256 @default.
- W4382136044 cites W2150591941 @default.
- W4382136044 cites W2153283736 @default.
- W4382136044 cites W2164794127 @default.
- W4382136044 cites W2168292600 @default.
- W4382136044 cites W2170919433 @default.
- W4382136044 cites W2279526500 @default.
- W4382136044 cites W2299692864 @default.
- W4382136044 cites W2342925175 @default.
- W4382136044 cites W2417453345 @default.
- W4382136044 cites W2547880937 @default.
- W4382136044 cites W2564076115 @default.
- W4382136044 cites W2605158646 @default.
- W4382136044 cites W2767584643 @default.
- W4382136044 cites W2890258450 @default.
- W4382136044 cites W2901824970 @default.
- W4382136044 cites W2920686772 @default.
- W4382136044 cites W3003025198 @default.
- W4382136044 cites W3008880234 @default.
- W4382136044 cites W3047177224 @default.
- W4382136044 cites W3089206797 @default.
- W4382136044 cites W3121042750 @default.
- W4382136044 cites W3206504722 @default.
- W4382136044 cites W4200550789 @default.
- W4382136044 cites W4221027059 @default.
- W4382136044 cites W4224989794 @default.
- W4382136044 cites W4310534296 @default.
- W4382136044 doi "https://doi.org/10.3390/molecules28134950" @default.
- W4382136044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37446611" @default.
- W4382136044 hasPublicationYear "2023" @default.
- W4382136044 type Work @default.
- W4382136044 citedByCount "0" @default.
- W4382136044 crossrefType "journal-article" @default.
- W4382136044 hasAuthorship W4382136044A5004943203 @default.
- W4382136044 hasAuthorship W4382136044A5029541493 @default.
- W4382136044 hasAuthorship W4382136044A5062647358 @default.
- W4382136044 hasAuthorship W4382136044A5066651403 @default.
- W4382136044 hasAuthorship W4382136044A5067717800 @default.
- W4382136044 hasAuthorship W4382136044A5086096052 @default.
- W4382136044 hasAuthorship W4382136044A5088879726 @default.
- W4382136044 hasBestOaLocation W43821360441 @default.
- W4382136044 hasConcept C109316439 @default.
- W4382136044 hasConcept C13965031 @default.
- W4382136044 hasConcept C155672457 @default.
- W4382136044 hasConcept C163588942 @default.
- W4382136044 hasConcept C171250308 @default.
- W4382136044 hasConcept C178790620 @default.
- W4382136044 hasConcept C185592680 @default.
- W4382136044 hasConcept C192562407 @default.
- W4382136044 hasConcept C202751555 @default.
- W4382136044 hasConcept C2778998842 @default.
- W4382136044 hasConcept C2779732960 @default.
- W4382136044 hasConcept C55493867 @default.
- W4382136044 hasConcept C71924100 @default.
- W4382136044 hasConcept C86181022 @default.
- W4382136044 hasConcept C98274493 @default.
- W4382136044 hasConceptScore W4382136044C109316439 @default.
- W4382136044 hasConceptScore W4382136044C13965031 @default.
- W4382136044 hasConceptScore W4382136044C155672457 @default.
- W4382136044 hasConceptScore W4382136044C163588942 @default.
- W4382136044 hasConceptScore W4382136044C171250308 @default.
- W4382136044 hasConceptScore W4382136044C178790620 @default.
- W4382136044 hasConceptScore W4382136044C185592680 @default.
- W4382136044 hasConceptScore W4382136044C192562407 @default.