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- W4382137585 abstract "Background: Impairment of higher language functions associated with natural spontaneous speech in multiple sclerosis (MS) remains underexplored. Objectives: We presented a fully automated method for discriminating MS patients from healthy controls based on lexical and syntactic linguistic features. Methods: We enrolled 120 MS individuals with Expanded Disability Status Scale ranging from 1 to 6.5 and 120 age-, sex-, and education-matched healthy controls. Linguistic analysis was performed with fully automated methods based on automatic speech recognition and natural language processing techniques using eight lexical and syntactic features acquired from the spontaneous discourse. Fully automated annotations were compared with human annotations. Results: Compared with healthy controls, lexical impairment in MS consisted of an increase in content words ( p = 0.037), a decrease in function words ( p = 0.007), and overuse of verbs at the expense of noun ( p = 0.047), while syntactic impairment manifested as shorter utterance length ( p = 0.002), and low number of coordinate clause ( p < 0.001). A fully automated language analysis approach enabled discrimination between MS and controls with an area under the curve of 0.70. A significant relationship was detected between shorter utterance length and lower symbol digit modalities test score ( r = 0.25, p = 0.008). Strong associations between a majority of automatically and manually computed features were observed ( r > 0.88, p < 0.001). Conclusion: Automated discourse analysis has the potential to provide an easy-to-implement and low-cost language-based biomarker of cognitive decline in MS for future clinical trials." @default.
- W4382137585 created "2023-06-27" @default.
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- W4382137585 date "2023-01-01" @default.
- W4382137585 modified "2023-10-01" @default.
- W4382137585 title "Lexical and syntactic deficits analyzed via automated natural language processing: the new monitoring tool in multiple sclerosis" @default.
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- W4382137585 doi "https://doi.org/10.1177/17562864231180719" @default.
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