Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382138039> ?p ?o ?g. }
- W4382138039 endingPage "3307" @default.
- W4382138039 startingPage "3307" @default.
- W4382138039 abstract "Glioblastoma is the most prevalent primary brain tumour and invariably confers a poor prognosis. The immense intra-tumoral heterogeneity of glioblastoma and its ability to rapidly develop treatment resistance are key barriers to successful therapy. As such, there is an urgent need for the greater understanding of the tumour biology in order to guide the development of novel therapeutics in this field. N6-methyladenosine (m6A) is the most abundant of the RNA modifications in eukaryotes. Studies have demonstrated that the regulation of this RNA modification is altered in glioblastoma and may serve to regulate diverse mechanisms including glioma stem-cell self-renewal, tumorigenesis, invasion and treatment evasion. However, the precise mechanisms by which m6A modifications exert their functional effects are poorly understood. This review summarises the evidence for the disordered regulation of m6A in glioblastoma and discusses the downstream functional effects of m6A modification on RNA fate. The wide-ranging biological consequences of m6A modification raises the hope that novel cancer therapies can be targeted against this mechanism." @default.
- W4382138039 created "2023-06-27" @default.
- W4382138039 creator A5015235828 @default.
- W4382138039 creator A5017321175 @default.
- W4382138039 creator A5051873002 @default.
- W4382138039 creator A5077186196 @default.
- W4382138039 date "2023-06-23" @default.
- W4382138039 modified "2023-10-18" @default.
- W4382138039 title "The Regulation of m6A Modification in Glioblastoma: Functional Mechanisms and Therapeutic Approaches" @default.
- W4382138039 cites W1538419182 @default.
- W4382138039 cites W1895681508 @default.
- W4382138039 cites W1941339056 @default.
- W4382138039 cites W1981587077 @default.
- W4382138039 cites W1981629946 @default.
- W4382138039 cites W1982602899 @default.
- W4382138039 cites W1991807334 @default.
- W4382138039 cites W2001533224 @default.
- W4382138039 cites W2009427752 @default.
- W4382138039 cites W2015696149 @default.
- W4382138039 cites W2021881561 @default.
- W4382138039 cites W2022770379 @default.
- W4382138039 cites W2036870885 @default.
- W4382138039 cites W2040827479 @default.
- W4382138039 cites W2044387885 @default.
- W4382138039 cites W2046851093 @default.
- W4382138039 cites W2065847836 @default.
- W4382138039 cites W2071930821 @default.
- W4382138039 cites W2078964320 @default.
- W4382138039 cites W2090854519 @default.
- W4382138039 cites W2091235283 @default.
- W4382138039 cites W2104301158 @default.
- W4382138039 cites W2119024338 @default.
- W4382138039 cites W2127307105 @default.
- W4382138039 cites W2132514587 @default.
- W4382138039 cites W2133150504 @default.
- W4382138039 cites W2138897067 @default.
- W4382138039 cites W2154345686 @default.
- W4382138039 cites W2156607330 @default.
- W4382138039 cites W2164105136 @default.
- W4382138039 cites W2165547003 @default.
- W4382138039 cites W2265820530 @default.
- W4382138039 cites W2276031634 @default.
- W4382138039 cites W2305853311 @default.
- W4382138039 cites W2306179365 @default.
- W4382138039 cites W2329246567 @default.
- W4382138039 cites W2419388116 @default.
- W4382138039 cites W2465868860 @default.
- W4382138039 cites W2475966948 @default.
- W4382138039 cites W2507685096 @default.
- W4382138039 cites W2515159273 @default.
- W4382138039 cites W2563912688 @default.
- W4382138039 cites W2597375791 @default.
- W4382138039 cites W2600626962 @default.
- W4382138039 cites W2600862208 @default.
- W4382138039 cites W2604499950 @default.
- W4382138039 cites W2613444330 @default.
- W4382138039 cites W2690599584 @default.
- W4382138039 cites W2715937868 @default.
- W4382138039 cites W2760498857 @default.
- W4382138039 cites W2761676504 @default.
- W4382138039 cites W2765639695 @default.
- W4382138039 cites W2772792536 @default.
- W4382138039 cites W2783571957 @default.
- W4382138039 cites W2790982207 @default.
- W4382138039 cites W2791349417 @default.
- W4382138039 cites W2791790309 @default.
- W4382138039 cites W2793785833 @default.
- W4382138039 cites W2800459978 @default.
- W4382138039 cites W2801863206 @default.
- W4382138039 cites W2803721679 @default.
- W4382138039 cites W2807565449 @default.
- W4382138039 cites W2885156893 @default.
- W4382138039 cites W2891713480 @default.
- W4382138039 cites W2899253639 @default.
- W4382138039 cites W2911349862 @default.
- W4382138039 cites W2911411569 @default.
- W4382138039 cites W2912993287 @default.
- W4382138039 cites W2913346540 @default.
- W4382138039 cites W2914006819 @default.
- W4382138039 cites W2917441328 @default.
- W4382138039 cites W2922454987 @default.
- W4382138039 cites W2924590478 @default.
- W4382138039 cites W2935697369 @default.
- W4382138039 cites W2946217053 @default.
- W4382138039 cites W2960264922 @default.
- W4382138039 cites W2966097303 @default.
- W4382138039 cites W2972933339 @default.
- W4382138039 cites W2974616751 @default.
- W4382138039 cites W2977517791 @default.
- W4382138039 cites W2979531443 @default.
- W4382138039 cites W2979999555 @default.
- W4382138039 cites W2981736386 @default.
- W4382138039 cites W2990143544 @default.
- W4382138039 cites W2992866845 @default.
- W4382138039 cites W2994940889 @default.
- W4382138039 cites W2995004160 @default.
- W4382138039 cites W2995711559 @default.
- W4382138039 cites W2997897999 @default.