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• W4382141014 abstract "Identifying a subgroup of patients who may have an enhanced treatment effect in a randomized clinical trial has received increasing attention recently. For time-to-event outcomes, it is a challenge to define the effectiveness of a treatment and to choose a cutoff time point for identifying subgroup membership, especially in trials in which the two treatment arms do not differ in overall survival. In this paper, we propose a mixture cure model to identify a subgroup for a new treatment that was compared to a classical treatment (or placebo) in a randomized clinical trial with respect to survival time. Using the concordance probability measurement (K-index), we propose a statistic to test the existence of subgroups with effective treatments in the treatment arm. Subsequently, the subgroup is defined by a limited number of covariates based on the estimated area under the curve (AUC). The performance of this method in different scenarios is assessed through simulation studies. A real data example is also provided for illustration." @default.
• W4382141014 created "2023-06-27" @default.
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• W4382141014 date "2023-06-26" @default.
• W4382141014 modified "2023-10-04" @default.
• W4382141014 title "Subgroup Identification in Survival Outcome Data Based on Concordance Probability Measurement" @default.
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• W4382141014 doi "https://doi.org/10.3390/math11132855" @default.
• W4382141014 hasPublicationYear "2023" @default.
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