FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382182138> ?p ?o ?g. }

• W4382182138 endingPage "10336" @default.
• W4382182138 startingPage "10330" @default.
• W4382182138 abstract "Small extracellular vesicles (sEVs) derived from tumors contain a vast amount of cellular information and are regarded as a potential diagnostic biomarker for noninvasive cancer diagnosis. Nevertheless, it remains challenging to accurately measure sEVs from clinical samples due to the low abundance of these vesicles as well as their phenotypic heterogeneity. Herein, a polymerase-driven logic signal amplification system (PLSAS) was developed for the high-sensitivity detection of sEV surface proteins and breast cancer (BC) identification. Aptamers were introduced to serve as sensing modules to specifically recognize target proteins. By changing the input DNA sequences, two polymerase-driven primer exchange reaction systems were rationally designed for DNA logic computing. This allows for autonomous targeting of a limited number of targets using “OR” and “AND” logic, leading to a significant increase in fluorescence signals and enabling the specific and ultrasensitive detection of sEV surface proteins. In this work, we investigated surface proteins of mucin 1 (MUC1) and the epithelial cell adhesion molecule (EpCAM) as model proteins. When MUC1 or EpCAM proteins were used as single signal input in the “OR” DNA logic system, the detection limit of sEVs was 24 or 58 particles/μL, respectively. And MUC1 and EpCAM proteins of sEVs can be simultaneously detected in the AND logic method, which can significantly reduce the effect of phenotypic heterogeneity of sEVs to distinguish the source of sEVs derived from various mammary cell lines, such as MCF-7, MDA MB 231, SKBR3, and MCF-10A. The approach has achieved high discrimination in serologically tested positive BC samples (AUC 98.1%) and holds significant potential in advancing the early diagnosis and prognostic assessments of BC." @default.
• W4382182138 created "2023-06-28" @default.
• W4382182138 creator A5002746422 @default.
• W4382182138 creator A5013678991 @default.
• W4382182138 creator A5085704253 @default.
• W4382182138 creator A5089536044 @default.
• W4382182138 date "2023-06-27" @default.
• W4382182138 modified "2023-10-16" @default.
• W4382182138 title "Polymerase-Driven Logic Signal Amplification for the Detection of Small Extracellular Vesicle Surface Proteins and the Identification of Breast Cancer" @default.
• W4382182138 cites W1937665132 @default.
• W4382182138 cites W2167722760 @default.
• W4382182138 cites W2296538017 @default.
• W4382182138 cites W2552248355 @default.
• W4382182138 cites W2553886049 @default.
• W4382182138 cites W2749821331 @default.
• W4382182138 cites W2767343818 @default.
• W4382182138 cites W2883593500 @default.
• W4382182138 cites W2895168297 @default.
• W4382182138 cites W2909853310 @default.
• W4382182138 cites W2940609124 @default.
• W4382182138 cites W2945773152 @default.
• W4382182138 cites W2963139878 @default.
• W4382182138 cites W2968292465 @default.
• W4382182138 cites W2984807823 @default.
• W4382182138 cites W2991412336 @default.
• W4382182138 cites W2996153633 @default.
• W4382182138 cites W2998903548 @default.
• W4382182138 cites W3005104290 @default.
• W4382182138 cites W3009515221 @default.
• W4382182138 cites W3012835096 @default.
• W4382182138 cites W3035199400 @default.
• W4382182138 cites W3036376280 @default.
• W4382182138 cites W3046136084 @default.
• W4382182138 cites W3080327845 @default.
• W4382182138 cites W3081542255 @default.
• W4382182138 cites W3084038322 @default.
• W4382182138 cites W3101476137 @default.
• W4382182138 cites W3114496642 @default.
• W4382182138 cites W3119671947 @default.
• W4382182138 cites W3125467709 @default.
• W4382182138 cites W3129300256 @default.
• W4382182138 cites W3154091431 @default.
• W4382182138 cites W3158685479 @default.
• W4382182138 cites W3168950117 @default.
• W4382182138 cites W3177937878 @default.
• W4382182138 cites W3182299790 @default.
• W4382182138 cites W3189674911 @default.
• W4382182138 cites W3194018776 @default.
• W4382182138 cites W3197164816 @default.
• W4382182138 cites W4205356212 @default.
• W4382182138 cites W4212964448 @default.
• W4382182138 cites W4213447794 @default.
• W4382182138 cites W4220908424 @default.
• W4382182138 cites W4223612966 @default.
• W4382182138 cites W4224079042 @default.
• W4382182138 cites W4240312877 @default.
• W4382182138 cites W4283388497 @default.
• W4382182138 cites W4313530504 @default.
• W4382182138 cites W4313545598 @default.
• W4382182138 cites W4316466614 @default.
• W4382182138 cites W4317886438 @default.
• W4382182138 cites W4319224657 @default.
• W4382182138 doi "https://doi.org/10.1021/acs.analchem.3c01080" @default.
• W4382182138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37366594" @default.
• W4382182138 hasPublicationYear "2023" @default.
• W4382182138 type Work @default.
• W4382182138 citedByCount "0" @default.
• W4382182138 crossrefType "journal-article" @default.
• W4382182138 hasAuthorship W4382182138A5002746422 @default.
• W4382182138 hasAuthorship W4382182138A5013678991 @default.
• W4382182138 hasAuthorship W4382182138A5085704253 @default.
• W4382182138 hasAuthorship W4382182138A5089536044 @default.
• W4382182138 hasConcept C121608353 @default.
• W4382182138 hasConcept C128972844 @default.
• W4382182138 hasConcept C1491633281 @default.
• W4382182138 hasConcept C153911025 @default.
• W4382182138 hasConcept C178790620 @default.
• W4382182138 hasConcept C185592680 @default.
• W4382182138 hasConcept C191560914 @default.
• W4382182138 hasConcept C2776677690 @default.
• W4382182138 hasConcept C2777563447 @default.
• W4382182138 hasConcept C2994423619 @default.
• W4382182138 hasConcept C54355233 @default.
• W4382182138 hasConcept C55493867 @default.
• W4382182138 hasConcept C70721500 @default.
• W4382182138 hasConcept C86803240 @default.
• W4382182138 hasConcept C95444343 @default.
• W4382182138 hasConcept C96232424 @default.
• W4382182138 hasConceptScore W4382182138C121608353 @default.
• W4382182138 hasConceptScore W4382182138C128972844 @default.
• W4382182138 hasConceptScore W4382182138C1491633281 @default.
• W4382182138 hasConceptScore W4382182138C153911025 @default.
• W4382182138 hasConceptScore W4382182138C178790620 @default.
• W4382182138 hasConceptScore W4382182138C185592680 @default.
• W4382182138 hasConceptScore W4382182138C191560914 @default.
• W4382182138 hasConceptScore W4382182138C2776677690 @default.
• W4382182138 hasConceptScore W4382182138C2777563447 @default.
• W4382182138 hasConceptScore W4382182138C2994423619 @default.

• next