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- W4382182914 abstract "The nuclear envelope and lamina regulate lipid metabolism and susceptibility to nonalcoholic steatohepatitis (NASH), but the role of the nuclear lamin-binding protein LAP2α in NASH has not been explored. Our data demonstrate that hepatocyte-specific loss of LAP2α protects against diet-induced hepatic steatosis, NASH, and fibrosis in male mice, with downregulation of pro-steatotic, pro-inflammatory, and pro-fibrotic lamin-regulated genes. These findings suggest that targeting LAP2α could have future potential as a novel therapeutic avenue in NASH." @default.
- W4382182914 created "2023-06-28" @default.
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- W4382182914 date "2023-08-01" @default.
- W4382182914 modified "2023-10-17" @default.
- W4382182914 title "Hepatocyte-specific loss of LAP2α protects against diet-induced hepatic steatosis, steatohepatitis, and fibrosis in male mice" @default.
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- W4382182914 doi "https://doi.org/10.1152/ajpgi.00214.2022" @default.
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