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• W4382195985 abstract "During Mohs surgery for melanoma, evidence has demonstrated that many surgeons opt for smaller initial margins than traditionally recommended (0.5 cm for in situ and 1 cm for invasive). Literature regarding surgical outcomes based on initial margin is sparse.To determine differences in disease-specific survival of melanoma after Mohs micrographic surgery for varied initial surgical margins.A literature search was conducted on February 14, 2022, from MEDLINE via PubMed (1946-present), Embase (1974-present), Central (1991-present), and Scopus (1960-present). The primary outcome was disease-specific mortality.Nineteen studies were included for final analysis. The overall disease-specific mortality rate of melanoma in all included studies was 0.5% (CI, 0.1-0.8; P, .010). Disease-specific mortality for 1 to 5, 5, and 6 to 10 mm categories were 0.4% (CI, 0.0-0.9; P, .074), 0.7% (CI, 0.2-1.3; P, .2-1.3), and 0.4% (CI, -0.9 to 1.8; P, .524), respectively. None of the variances across initial margin categories were statistically significant.Early-stage melanomas have low overall mortality rates. In our associated article, initial margins of 5 to 10 mm were shown to have the lowest rates of local recurrence.In this systematic review and meta-analysis, melanoma-specific mortality was not significantly impacted by the initial surgical margin taken during Mohs micrographic surgery." @default.
• W4382195985 created "2023-06-28" @default.
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• W4382195985 date "2023-12-01" @default.
• W4382195985 modified "2023-10-14" @default.
• W4382195985 title "Disease-specific Survival of Malignant Melanoma after Mohs Micrographic Surgery is Not Impacted by Initial Margins: A Systematic Review and Meta-Analysis" @default.
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• W4382195985 doi "https://doi.org/10.1016/j.jdin.2023.06.009" @default.
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