FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382197462> ?p ?o ?g. }

• W4382197462 abstract "The composition, elasticity, and organization of the extracellular matrix within the central nervous system contribute to the architecture and function of the brain. From an in vitro modeling perspective, soft biomaterials are needed to mimic the 3D neural microenvironments. While many studies have investigated 3D culture and neural network formation in bulk hydrogel systems, these approaches have limited ability to position cells to mimic sophisticated brain architectures. In this study, cortical neurons and astrocytes acutely isolated from the brains of rats are bioprinted in a hydrogel to form 3D neuronal constructs. Successful bioprinting of cellular and acellular strands in a multi-bioink approach allows the subsequent formation of gray- and white-matter tracts reminiscent of cortical structures. Immunohistochemistry shows the formation of dense, 3D axon networks. Calcium signaling and extracellular electrophysiology in these 3D neuronal networks confirm spontaneous activity in addition to evoked activities under pharmacological and electrical stimulation. The system and bioprinting approaches are capable of fabricating soft, free-standing neuronal structures of different bioink and cell types with high resolution and throughput, which provide a promising platform for understanding fundamental questions of neural networks, engineering neuromorphic circuits, and for in vitro drug screening." @default.
• W4382197462 created "2023-06-28" @default.
• W4382197462 creator A5000151848 @default.
• W4382197462 creator A5006764099 @default.
• W4382197462 creator A5024023946 @default.
• W4382197462 creator A5029409684 @default.
• W4382197462 creator A5046202195 @default.
• W4382197462 date "2023-07-09" @default.
• W4382197462 modified "2023-10-17" @default.
• W4382197462 title "3D Functional Neuronal Networks in Free‐Standing Bioprinted Hydrogel Constructs" @default.
• W4382197462 cites W1529448825 @default.
• W4382197462 cites W1862832045 @default.
• W4382197462 cites W1974861764 @default.
• W4382197462 cites W1976632391 @default.
• W4382197462 cites W1976805317 @default.
• W4382197462 cites W1999287295 @default.
• W4382197462 cites W2002095196 @default.
• W4382197462 cites W2022549449 @default.
• W4382197462 cites W2022667586 @default.
• W4382197462 cites W2054465718 @default.
• W4382197462 cites W2064241002 @default.
• W4382197462 cites W2088422474 @default.
• W4382197462 cites W2097722670 @default.
• W4382197462 cites W2099540110 @default.
• W4382197462 cites W2165420108 @default.
• W4382197462 cites W2291174253 @default.
• W4382197462 cites W2330595735 @default.
• W4382197462 cites W2401629147 @default.
• W4382197462 cites W2546592055 @default.
• W4382197462 cites W2617480969 @default.
• W4382197462 cites W2742887083 @default.
• W4382197462 cites W2768421776 @default.
• W4382197462 cites W2784363986 @default.
• W4382197462 cites W2887331259 @default.
• W4382197462 cites W2889769582 @default.
• W4382197462 cites W2954108631 @default.
• W4382197462 cites W2977759181 @default.
• W4382197462 cites W2993816101 @default.
• W4382197462 cites W3001213913 @default.
• W4382197462 cites W3092403194 @default.
• W4382197462 cites W3123833583 @default.
• W4382197462 cites W4280505892 @default.
• W4382197462 doi "https://doi.org/10.1002/adhm.202300801" @default.
• W4382197462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37369123" @default.
• W4382197462 hasPublicationYear "2023" @default.
• W4382197462 type Work @default.
• W4382197462 citedByCount "0" @default.
• W4382197462 crossrefType "journal-article" @default.
• W4382197462 hasAuthorship W4382197462A5000151848 @default.
• W4382197462 hasAuthorship W4382197462A5006764099 @default.
• W4382197462 hasAuthorship W4382197462A5024023946 @default.
• W4382197462 hasAuthorship W4382197462A5029409684 @default.
• W4382197462 hasAuthorship W4382197462A5046202195 @default.
• W4382197462 hasBestOaLocation W43821974621 @default.
• W4382197462 hasConcept C108586683 @default.
• W4382197462 hasConcept C118403218 @default.
• W4382197462 hasConcept C136229726 @default.
• W4382197462 hasConcept C169760540 @default.
• W4382197462 hasConcept C171250308 @default.
• W4382197462 hasConcept C188027245 @default.
• W4382197462 hasConcept C189165786 @default.
• W4382197462 hasConcept C192562407 @default.
• W4382197462 hasConcept C2779718196 @default.
• W4382197462 hasConcept C41008148 @default.
• W4382197462 hasConcept C49892992 @default.
• W4382197462 hasConcept C71924100 @default.
• W4382197462 hasConcept C86803240 @default.
• W4382197462 hasConcept C95444343 @default.
• W4382197462 hasConceptScore W4382197462C108586683 @default.
• W4382197462 hasConceptScore W4382197462C118403218 @default.
• W4382197462 hasConceptScore W4382197462C136229726 @default.
• W4382197462 hasConceptScore W4382197462C169760540 @default.
• W4382197462 hasConceptScore W4382197462C171250308 @default.
• W4382197462 hasConceptScore W4382197462C188027245 @default.
• W4382197462 hasConceptScore W4382197462C189165786 @default.
• W4382197462 hasConceptScore W4382197462C192562407 @default.
• W4382197462 hasConceptScore W4382197462C2779718196 @default.
• W4382197462 hasConceptScore W4382197462C41008148 @default.
• W4382197462 hasConceptScore W4382197462C49892992 @default.
• W4382197462 hasConceptScore W4382197462C71924100 @default.
• W4382197462 hasConceptScore W4382197462C86803240 @default.
• W4382197462 hasConceptScore W4382197462C95444343 @default.
• W4382197462 hasFunder F4320320971 @default.
• W4382197462 hasFunder F4320321981 @default.
• W4382197462 hasLocation W43821974621 @default.
• W4382197462 hasLocation W43821974622 @default.
• W4382197462 hasOpenAccess W4382197462 @default.
• W4382197462 hasPrimaryLocation W43821974621 @default.
• W4382197462 hasRelatedWork W1966288407 @default.
• W4382197462 hasRelatedWork W2038809418 @default.
• W4382197462 hasRelatedWork W2277257395 @default.
• W4382197462 hasRelatedWork W2809376314 @default.
• W4382197462 hasRelatedWork W2883509016 @default.
• W4382197462 hasRelatedWork W2959708895 @default.
• W4382197462 hasRelatedWork W3186190873 @default.
• W4382197462 hasRelatedWork W4211054287 @default.
• W4382197462 hasRelatedWork W4328026294 @default.
• W4382197462 hasRelatedWork W2485176123 @default.
• W4382197462 isParatext "false" @default.
• W4382197462 isRetracted "false" @default.

• next