Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382197593> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4382197593 abstract "Abstract: OTUD6A is a deubiquitinase that plays crucial roles in various human diseases. However, the precise regulatory mechanism of OTUD6A remains unclear. In this study, we found that OTUD6A significantly inhibited the production of type I interferon. Consistently, peritoneal macrophages and bone marrow-derived macrophages from Otud6a-/- mice produced more type I interferon after virus infection compared to cells from WT mice. Otud6a-/- mice also exhibited increased resistance to lethal HSV-1 and VSV infections, as well as LPS attack due to decreased inflammatory responses. Mechanistically, mass spectrometry results revealed that UBC13 was an OTUD6A-interacting protein, and the interaction significantly enhanced after HSV-1 stimulation. Taken together, our findings suggest that OTUD6A plays a crucial role in the innate immune response and may serve as a potential therapeutic target for infectious disease." @default.
- W4382197593 created "2023-06-28" @default.
- W4382197593 creator A5007506428 @default.
- W4382197593 creator A5012837541 @default.
- W4382197593 creator A5022049957 @default.
- W4382197593 creator A5051928983 @default.
- W4382197593 creator A5056678009 @default.
- W4382197593 creator A5060971135 @default.
- W4382197593 creator A5063347622 @default.
- W4382197593 creator A5070356956 @default.
- W4382197593 creator A5088415479 @default.
- W4382197593 creator A5090856797 @default.
- W4382197593 date "2023-06-27" @default.
- W4382197593 modified "2023-09-26" @default.
- W4382197593 title "Deubiquitinase OTUD6A Regulates Innate Immune Response Via Targeting Ubc13" @default.
- W4382197593 doi "https://doi.org/10.20944/preprints202306.1894.v1" @default.
- W4382197593 hasPublicationYear "2023" @default.
- W4382197593 type Work @default.
- W4382197593 citedByCount "0" @default.
- W4382197593 crossrefType "posted-content" @default.
- W4382197593 hasAuthorship W4382197593A5007506428 @default.
- W4382197593 hasAuthorship W4382197593A5012837541 @default.
- W4382197593 hasAuthorship W4382197593A5022049957 @default.
- W4382197593 hasAuthorship W4382197593A5051928983 @default.
- W4382197593 hasAuthorship W4382197593A5056678009 @default.
- W4382197593 hasAuthorship W4382197593A5060971135 @default.
- W4382197593 hasAuthorship W4382197593A5063347622 @default.
- W4382197593 hasAuthorship W4382197593A5070356956 @default.
- W4382197593 hasAuthorship W4382197593A5088415479 @default.
- W4382197593 hasAuthorship W4382197593A5090856797 @default.
- W4382197593 hasBestOaLocation W43821975931 @default.
- W4382197593 hasConcept C136449434 @default.
- W4382197593 hasConcept C169760540 @default.
- W4382197593 hasConcept C203014093 @default.
- W4382197593 hasConcept C24998067 @default.
- W4382197593 hasConcept C2776178377 @default.
- W4382197593 hasConcept C86803240 @default.
- W4382197593 hasConcept C8891405 @default.
- W4382197593 hasConceptScore W4382197593C136449434 @default.
- W4382197593 hasConceptScore W4382197593C169760540 @default.
- W4382197593 hasConceptScore W4382197593C203014093 @default.
- W4382197593 hasConceptScore W4382197593C24998067 @default.
- W4382197593 hasConceptScore W4382197593C2776178377 @default.
- W4382197593 hasConceptScore W4382197593C86803240 @default.
- W4382197593 hasConceptScore W4382197593C8891405 @default.
- W4382197593 hasLocation W43821975931 @default.
- W4382197593 hasOpenAccess W4382197593 @default.
- W4382197593 hasPrimaryLocation W43821975931 @default.
- W4382197593 hasRelatedWork W1175477002 @default.
- W4382197593 hasRelatedWork W2039268906 @default.
- W4382197593 hasRelatedWork W2141330728 @default.
- W4382197593 hasRelatedWork W2155374266 @default.
- W4382197593 hasRelatedWork W2336355791 @default.
- W4382197593 hasRelatedWork W2413321539 @default.
- W4382197593 hasRelatedWork W2520162260 @default.
- W4382197593 hasRelatedWork W2973429485 @default.
- W4382197593 hasRelatedWork W4281729072 @default.
- W4382197593 hasRelatedWork W4321850089 @default.
- W4382197593 isParatext "false" @default.
- W4382197593 isRetracted "false" @default.
- W4382197593 workType "article" @default.