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• W4382198488 abstract "Abstract Background and objective : Autologous blood transfusion is a form of “blood doping” banned by the World Anti-Doping Agency. At present, this practice is detectable exclusively by the individual, longitudinal monitoring of hematological biomarkers, as in the hematological module of the Athlete Biological Passport; but this indirect approach may suffer from different confounding factors. We are presenting a multi-parametric, analytical strategy to detect autologous blood transfusions by targeting the modification of the red blood cells during storage. We focused on the assessment of “storage lesions” that occur to red blood cells between the withdrawal and the re-infusion. Methods : We specifically focused on (i) membrane proteins: Glycophorin-A and Band 3 complex, (ii) biomarkers of oxidative stress: Peroxiredoxin-2 (PRDX2), (iii) biomarkers of senescence: CD47 and Phosphatidylserine, (iv) erythrocytes microparticles. All of the above were monitored, by immunological and flow cytofluorimetric methods, on samples of stored whole blood collected at different time intervals, and on fresh and blood samples mixed “ex vivo” to simulate an autotransfusion. Results : Our results showed that the irreversible alteration of RBCs morphology, the loss of membrane integrity, the occurrence of hemolysis phenomena, and, more in general, the “aging” of the erythrocytes during storage are closely related to the reduced concentration of Band 3 protein and glycophorin A in the erythrocyte membrane, to the externalization of phosphatidyl serine and to the reduced concentration of CD47. In parallel, increasing levels of erythrocyte microparticles are produced during storage. Conclusions : The most promising method to detect the presence of transfused blood in whole blood samples can be based on a multi-parametric strategy, considering jointly both protein expression on RBCs membranes and micro-vesiculation phenomena." @default.
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• W4382198488 date "2023-06-27" @default.
• W4382198488 modified "2023-10-14" @default.
• W4382198488 title "Towards the development of a direct method for the detection of autologous blood transfusions in sport doping: targeting the red blood cells “storage lesions”" @default.
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• W4382198488 doi "https://doi.org/10.21203/rs.3.rs-3000420/v1" @default.
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