Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382198968> ?p ?o ?g. }
- W4382198968 abstract "Abstract Immunodominance of antibodies targeting non-neutralizing epitopes and the high level of somatic hypermutation within germinal centers (GCs) required for most HIV broadly neutralizing antibodies (bnAbs) are major impediments to the development of an effective HIV vaccine. Rational protein vaccine design and non-conventional immunization strategies are potential avenues to overcome these hurdles. Here, we report using implantable osmotic pumps to continuously deliver a series of epitope-targeted immunogens to rhesus macaques over the course of six months to elicit immune responses against the conserved fusion peptide. Antibody specificities and GC responses were tracked longitudinally using electron microscopy polyclonal epitope mapping (EMPEM) and lymph node fine-needle aspirates, respectively. Application of cryoEMPEM delineated key residues for on-target and off-target responses that can drive the next round of structure-based vaccine design." @default.
- W4382198968 created "2023-06-28" @default.
- W4382198968 creator A5004036928 @default.
- W4382198968 creator A5009266880 @default.
- W4382198968 creator A5010618682 @default.
- W4382198968 creator A5012087658 @default.
- W4382198968 creator A5015116409 @default.
- W4382198968 creator A5018118849 @default.
- W4382198968 creator A5026313525 @default.
- W4382198968 creator A5030160770 @default.
- W4382198968 creator A5043974839 @default.
- W4382198968 creator A5046934232 @default.
- W4382198968 creator A5048618426 @default.
- W4382198968 creator A5050028736 @default.
- W4382198968 creator A5054741005 @default.
- W4382198968 creator A5057397000 @default.
- W4382198968 creator A5058546353 @default.
- W4382198968 creator A5058576287 @default.
- W4382198968 creator A5062692822 @default.
- W4382198968 creator A5064338113 @default.
- W4382198968 creator A5076138661 @default.
- W4382198968 creator A5076960340 @default.
- W4382198968 creator A5079502917 @default.
- W4382198968 creator A5079989868 @default.
- W4382198968 creator A5087926553 @default.
- W4382198968 creator A5091875762 @default.
- W4382198968 date "2023-06-27" @default.
- W4382198968 modified "2023-09-27" @default.
- W4382198968 title "Focusing antibody responses to the fusion peptide in rhesus macaques" @default.
- W4382198968 cites W1520886481 @default.
- W4382198968 cites W1838872057 @default.
- W4382198968 cites W1920682071 @default.
- W4382198968 cites W1967115540 @default.
- W4382198968 cites W1972341594 @default.
- W4382198968 cites W1983225666 @default.
- W4382198968 cites W1997677784 @default.
- W4382198968 cites W2006790382 @default.
- W4382198968 cites W2008830902 @default.
- W4382198968 cites W2029135056 @default.
- W4382198968 cites W2046563994 @default.
- W4382198968 cites W2051397298 @default.
- W4382198968 cites W2066082644 @default.
- W4382198968 cites W2074179519 @default.
- W4382198968 cites W2076449818 @default.
- W4382198968 cites W2078437475 @default.
- W4382198968 cites W2080746125 @default.
- W4382198968 cites W2082208556 @default.
- W4382198968 cites W2084310667 @default.
- W4382198968 cites W2086853340 @default.
- W4382198968 cites W2087090401 @default.
- W4382198968 cites W2093961711 @default.
- W4382198968 cites W2104130324 @default.
- W4382198968 cites W2113236498 @default.
- W4382198968 cites W2116563764 @default.
- W4382198968 cites W2119704168 @default.
- W4382198968 cites W2122210861 @default.
- W4382198968 cites W2124026197 @default.
- W4382198968 cites W2126255146 @default.
- W4382198968 cites W2132629607 @default.
- W4382198968 cites W2134803208 @default.
- W4382198968 cites W2137939749 @default.
- W4382198968 cites W2146478787 @default.
- W4382198968 cites W2146704167 @default.
- W4382198968 cites W2150759879 @default.
- W4382198968 cites W2156754803 @default.
- W4382198968 cites W2172848756 @default.
- W4382198968 cites W2180229411 @default.
- W4382198968 cites W2210879955 @default.
- W4382198968 cites W2332658587 @default.
- W4382198968 cites W2342500021 @default.
- W4382198968 cites W2380132702 @default.
- W4382198968 cites W2381153372 @default.
- W4382198968 cites W2511617912 @default.
- W4382198968 cites W2518999491 @default.
- W4382198968 cites W2527863850 @default.
- W4382198968 cites W2550740111 @default.
- W4382198968 cites W2554071243 @default.
- W4382198968 cites W2582690078 @default.
- W4382198968 cites W2587625522 @default.
- W4382198968 cites W2593511418 @default.
- W4382198968 cites W2606178393 @default.
- W4382198968 cites W2607106726 @default.
- W4382198968 cites W2721821765 @default.
- W4382198968 cites W2749697150 @default.
- W4382198968 cites W2765322245 @default.
- W4382198968 cites W2789134153 @default.
- W4382198968 cites W2795673173 @default.
- W4382198968 cites W2799119185 @default.
- W4382198968 cites W2887331716 @default.
- W4382198968 cites W2894112953 @default.
- W4382198968 cites W2896671589 @default.
- W4382198968 cites W2899714098 @default.
- W4382198968 cites W2911813404 @default.
- W4382198968 cites W2950967305 @default.
- W4382198968 cites W2951936481 @default.
- W4382198968 cites W2962804212 @default.
- W4382198968 cites W3011214629 @default.
- W4382198968 cites W3011701994 @default.
- W4382198968 cites W30316958 @default.
- W4382198968 cites W3033626306 @default.