FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382199159> ?p ?o ?g. }

• W4382199159 abstract "Abstract Pulmonary arterial hypertension (PAH) is a rare pulmonary vascular disease characterized by progressive pulmonary arterial remodeling, increased pulmonary vascular resistance, right ventricular dysfunction, and reduced survival. Effective therapies have been developed that target three pathobiologic pathways in PAH: nitric oxide, endothelin-1, and prostacyclin. Approved therapies for PAH include phosphodiesterase type-5 inhibitors, soluble guanylate cyclase stimulators, endothelin receptor antagonists, prostacyclin analogs, and prostacyclin receptor agonists. Management of PAH in the modern era incorporates multidimensional risk assessment to guide the use of these medications. For patients with PAH and without significant comorbidities, current guidelines recommend two oral medications (phosphodiesterase type-5 inhibitor and endothelin receptor antagonist) for low- and intermediate-risk patients, with triple therapy including a parenteral prostacyclin to be considered in those at high or intermediate-high risk. Combination therapy may be poorly tolerated and less effective in patients with PAH and cardiopulmonary comorbidities. Thus, a single-agent approach with individualized decisions to add-on other PAH therapies is recommended in older patients and those with significant comorbid conditions. Management of PAH is best performed in multidisciplinary teams located in experienced centers. Other core pillars of PAH management include supportive and adjunctive treatments including oxygen, diuretics, rehabilitation, and anticoagulation in certain patients. Patients with PAH who progress despite optimal treatment or who are refractory to best medical care should be referred for lung transplantation, if eligible. Despite considerable progress, PAH is often fatal and new therapies that reverse the disease and improve outcomes are desperately needed." @default.
• W4382199159 created "2023-06-28" @default.
• W4382199159 creator A5043292385 @default.
• W4382199159 creator A5047118206 @default.
• W4382199159 creator A5080539014 @default.
• W4382199159 creator A5082059107 @default.
• W4382199159 date "2023-06-27" @default.
• W4382199159 modified "2023-09-26" @default.
• W4382199159 title "Management of Pulmonary Arterial Hypertension" @default.
• W4382199159 cites W13250750 @default.
• W4382199159 cites W1497728164 @default.
• W4382199159 cites W1813220126 @default.
• W4382199159 cites W1840736932 @default.
• W4382199159 cites W1866413456 @default.
• W4382199159 cites W1936073859 @default.
• W4382199159 cites W1975889620 @default.
• W4382199159 cites W1978734517 @default.
• W4382199159 cites W1983657617 @default.
• W4382199159 cites W1997208142 @default.
• W4382199159 cites W1997713908 @default.
• W4382199159 cites W2000549992 @default.
• W4382199159 cites W2018759973 @default.
• W4382199159 cites W2023103539 @default.
• W4382199159 cites W2038402071 @default.
• W4382199159 cites W2043978435 @default.
• W4382199159 cites W2045150258 @default.
• W4382199159 cites W2048443661 @default.
• W4382199159 cites W2051069436 @default.
• W4382199159 cites W2057857083 @default.
• W4382199159 cites W2059367168 @default.
• W4382199159 cites W2067426756 @default.
• W4382199159 cites W2072760771 @default.
• W4382199159 cites W2073264366 @default.
• W4382199159 cites W2077929909 @default.
• W4382199159 cites W2084157495 @default.
• W4382199159 cites W2088289263 @default.
• W4382199159 cites W2090144219 @default.
• W4382199159 cites W2090213540 @default.
• W4382199159 cites W2093943199 @default.
• W4382199159 cites W2098625817 @default.
• W4382199159 cites W2099314224 @default.
• W4382199159 cites W2105296252 @default.
• W4382199159 cites W2107011819 @default.
• W4382199159 cites W2110637500 @default.
• W4382199159 cites W2112229901 @default.
• W4382199159 cites W2114698211 @default.
• W4382199159 cites W2120122350 @default.
• W4382199159 cites W2121376498 @default.
• W4382199159 cites W2126939785 @default.
• W4382199159 cites W2129282733 @default.
• W4382199159 cites W2132587013 @default.
• W4382199159 cites W2135608965 @default.
• W4382199159 cites W2143132974 @default.
• W4382199159 cites W2145254726 @default.
• W4382199159 cites W2146177859 @default.
• W4382199159 cites W2147841879 @default.
• W4382199159 cites W2148038451 @default.
• W4382199159 cites W2158575899 @default.
• W4382199159 cites W2158862125 @default.
• W4382199159 cites W2161167348 @default.
• W4382199159 cites W2161450347 @default.
• W4382199159 cites W2166811364 @default.
• W4382199159 cites W2173294927 @default.
• W4382199159 cites W2184677300 @default.
• W4382199159 cites W2231490797 @default.
• W4382199159 cites W2278696749 @default.
• W4382199159 cites W2290518504 @default.
• W4382199159 cites W2303061015 @default.
• W4382199159 cites W2310788539 @default.
• W4382199159 cites W2321522617 @default.
• W4382199159 cites W2326860105 @default.
• W4382199159 cites W2331798828 @default.
• W4382199159 cites W2337418714 @default.
• W4382199159 cites W2482228149 @default.
• W4382199159 cites W2485856646 @default.
• W4382199159 cites W2558016580 @default.
• W4382199159 cites W2560249286 @default.
• W4382199159 cites W2592637906 @default.
• W4382199159 cites W2619684371 @default.
• W4382199159 cites W2621229357 @default.
• W4382199159 cites W2621496307 @default.
• W4382199159 cites W2731289476 @default.
• W4382199159 cites W2736506498 @default.
• W4382199159 cites W2743897368 @default.
• W4382199159 cites W2744074505 @default.
• W4382199159 cites W2770181421 @default.
• W4382199159 cites W2773197749 @default.
• W4382199159 cites W2773437079 @default.
• W4382199159 cites W2775159846 @default.
• W4382199159 cites W2782480688 @default.
• W4382199159 cites W2796189912 @default.
• W4382199159 cites W2802328792 @default.
• W4382199159 cites W2889581918 @default.
• W4382199159 cites W2891121766 @default.
• W4382199159 cites W2897313468 @default.
• W4382199159 cites W2897755605 @default.
• W4382199159 cites W2899585138 @default.
• W4382199159 cites W2904085911 @default.
• W4382199159 cites W2904180601 @default.
• W4382199159 cites W2904385559 @default.

• next