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• W4382199706 endingPage "115586" @default.
• W4382199706 startingPage "115586" @default.
• W4382199706 abstract "Human immunodeficiency virus (HIV) is the etiological agent of acquired immunodeficiency syndrome (AIDS). Nowadays, FDA has approved over thirty antiretroviral drugs grouped in six categories. Interestingly, one-third of these drugs contain different number of fluorine atoms. The introduction of fluorine to obtain drug-like compounds is a well-accepted strategy in medicinal chemistry. In this review, we summarized 11 fluorine-containing anti-HIV drugs, focusing on their efficacy, resistance, safety, and specific roles of fluorine in the development of each drug. These examples may be of help for the discovery of new drug candidates bearing fluorine in their structures." @default.
• W4382199706 created "2023-06-28" @default.
• W4382199706 creator A5020533472 @default.
• W4382199706 creator A5078354859 @default.
• W4382199706 date "2023-10-01" @default.
• W4382199706 modified "2023-10-17" @default.
• W4382199706 title "Fluorine in anti-HIV drugs approved by FDA from 1981 to 2023" @default.
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