FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382203232> ?p ?o ?g. }

• W4382203232 abstract "Dendritic cells (DCs) that express T cell immunoglobulin domain molecule-4 (TIM4), a cell surface receptor for phosphatidylserine, induce T helper 2 (TH2) cell responses and allergic reactions. We elucidated the role of the transcription factor X-box-binding protein-1 (XBP1) in the induction of the TH2 cell response through its role in generating TIM4+ DCs. We found that XBP1 was required for TIM4 mRNA and protein expression in airway DCs in response to the cytokine interleukin-2 (IL-2) and that this pathway was required for TIM4 expression on DCs in response to the allergens PM2.5 and Derf1. The IL-2-XBP1-TIM4 axis in DCs contributed to Derf1/PM2.5-induced, aberrant TH2 cell responses in vivo. An interaction between the guanine nucleotide exchange factor Son of sevenless-1 (SOS1) and the GTPase RAS promoted XBP1 and TIM4 production in DCs. Targeting the XBP1-TIM4 pathway in DCs prevented or alleviated experimental airway allergy. Together, these data suggest that XBP1 is required for TH2 cell responses by inducing the development of TIM4+ DCs, which depends on the IL-2-XBP1-SOS1 axis. This signaling pathway provides potential therapeutic targets for the treatment of TH2 cell-dependent inflammation or allergic diseases." @default.
• W4382203232 created "2023-06-28" @default.
• W4382203232 creator A5005117527 @default.
• W4382203232 creator A5009638692 @default.
• W4382203232 creator A5010924929 @default.
• W4382203232 creator A5014112819 @default.
• W4382203232 creator A5021295478 @default.
• W4382203232 creator A5028397885 @default.
• W4382203232 creator A5045736183 @default.
• W4382203232 creator A5046696031 @default.
• W4382203232 creator A5058569786 @default.
• W4382203232 creator A5065819333 @default.
• W4382203232 creator A5071991576 @default.
• W4382203232 creator A5076395831 @default.
• W4382203232 creator A5077674515 @default.
• W4382203232 creator A5087615010 @default.
• W4382203232 creator A5088157068 @default.
• W4382203232 creator A5088532722 @default.
• W4382203232 creator A5092276274 @default.
• W4382203232 date "2023-06-27" @default.
• W4382203232 modified "2023-10-18" @default.
• W4382203232 title "The transcription factor XBP1 in dendritic cells promotes the T _H 2 cell response in airway allergy" @default.
• W4382203232 cites W1558405203 @default.
• W4382203232 cites W1561349380 @default.
• W4382203232 cites W1955652166 @default.
• W4382203232 cites W1993688639 @default.
• W4382203232 cites W2045680696 @default.
• W4382203232 cites W2048902759 @default.
• W4382203232 cites W2050895276 @default.
• W4382203232 cites W2051447573 @default.
• W4382203232 cites W2065937821 @default.
• W4382203232 cites W2078001123 @default.
• W4382203232 cites W2088531889 @default.
• W4382203232 cites W2090163544 @default.
• W4382203232 cites W2103639573 @default.
• W4382203232 cites W2903350032 @default.
• W4382203232 cites W2911727943 @default.
• W4382203232 cites W2912277053 @default.
• W4382203232 cites W2944778679 @default.
• W4382203232 cites W2945085089 @default.
• W4382203232 cites W2956129706 @default.
• W4382203232 cites W2958077316 @default.
• W4382203232 cites W2989387466 @default.
• W4382203232 cites W2990307798 @default.
• W4382203232 cites W3015021261 @default.
• W4382203232 cites W3015185997 @default.
• W4382203232 cites W3021309215 @default.
• W4382203232 cites W3022099302 @default.
• W4382203232 cites W3028481751 @default.
• W4382203232 cites W3086694166 @default.
• W4382203232 cites W3093237912 @default.
• W4382203232 cites W3093641991 @default.
• W4382203232 cites W3097905741 @default.
• W4382203232 cites W3101663251 @default.
• W4382203232 cites W3109451132 @default.
• W4382203232 cites W3110800072 @default.
• W4382203232 cites W3133345214 @default.
• W4382203232 cites W3166630584 @default.
• W4382203232 cites W3183637498 @default.
• W4382203232 cites W4211143846 @default.
• W4382203232 cites W4211175431 @default.
• W4382203232 doi "https://doi.org/10.1126/scisignal.abm9454" @default.
• W4382203232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37368951" @default.
• W4382203232 hasPublicationYear "2023" @default.
• W4382203232 type Work @default.
• W4382203232 citedByCount "0" @default.
• W4382203232 crossrefType "journal-article" @default.
• W4382203232 hasAuthorship W4382203232A5005117527 @default.
• W4382203232 hasAuthorship W4382203232A5009638692 @default.
• W4382203232 hasAuthorship W4382203232A5010924929 @default.
• W4382203232 hasAuthorship W4382203232A5014112819 @default.
• W4382203232 hasAuthorship W4382203232A5021295478 @default.
• W4382203232 hasAuthorship W4382203232A5028397885 @default.
• W4382203232 hasAuthorship W4382203232A5045736183 @default.
• W4382203232 hasAuthorship W4382203232A5046696031 @default.
• W4382203232 hasAuthorship W4382203232A5058569786 @default.
• W4382203232 hasAuthorship W4382203232A5065819333 @default.
• W4382203232 hasAuthorship W4382203232A5071991576 @default.
• W4382203232 hasAuthorship W4382203232A5076395831 @default.
• W4382203232 hasAuthorship W4382203232A5077674515 @default.
• W4382203232 hasAuthorship W4382203232A5087615010 @default.
• W4382203232 hasAuthorship W4382203232A5088157068 @default.
• W4382203232 hasAuthorship W4382203232A5088532722 @default.
• W4382203232 hasAuthorship W4382203232A5092276274 @default.
• W4382203232 hasConcept C104317684 @default.
• W4382203232 hasConcept C203014093 @default.
• W4382203232 hasConcept C2776090121 @default.
• W4382203232 hasConcept C2778170410 @default.
• W4382203232 hasConcept C2781331208 @default.
• W4382203232 hasConcept C54458228 @default.
• W4382203232 hasConcept C55493867 @default.
• W4382203232 hasConcept C67662055 @default.
• W4382203232 hasConcept C67705224 @default.
• W4382203232 hasConcept C86803240 @default.
• W4382203232 hasConcept C8891405 @default.
• W4382203232 hasConcept C95444343 @default.
• W4382203232 hasConceptScore W4382203232C104317684 @default.
• W4382203232 hasConceptScore W4382203232C203014093 @default.
• W4382203232 hasConceptScore W4382203232C2776090121 @default.
• W4382203232 hasConceptScore W4382203232C2778170410 @default.

• next