Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382238369> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4382238369 abstract "Background and Aims: Cancer chemotherapeutic agents cause alteration in the response to neuromuscular blocking drugs, which can have serious perioperative implications. Magnesium, commonly found to be deficient in these patients, plays an indispensable role in neuromuscular transmission. This study aimed to understand the effect of neoadjuvant chemotherapy on the neuromuscular blocking properties of cisatracurium. Material and Methods: One hundred female patients scheduled for breast cancer surgery were divided into two groups (n = 50 each). Group B received neoadjuvant chemotherapy with taxane, adriamycin, and cyclophosphamide, and Group A did not receive neoadjuvant chemotherapy. Neuromuscular block following cisatracurium 0.15 mg/kg was measured using peripheral nerve stimulator at the ulnar nerve. Onset time, duration of intense block, clinical duration of action, time to TOF4 after the last dose of cisatracurium, along with preoperative serum magnesium concentration were measured. Correlation and multiple regression were run to analyze the relationship between history of neoadjuvant chemotherapy, preoperative magnesium, and the abovementioned time points. Mediation analysis was done to ascertain if magnesium was mediating the observed effects. Results: Onset time was prolonged by nearly 18% in Group B compared to Group A (P = 0.001). The duration of intense block was 35.27 ± 8.9 min in Group B and 42.07 ± 10.99 min in Group A (P < 0.001). The clinical duration of action of cisatracurium was significantly shorter in Group B (46.06 ± 8.68 min) compared to Group A (55.87 ± 11.04 min, P < 0.001). The time to TOF4 was 32.86 ± 5.66 min in Group B and 36.57 ± 8.49 min in Group A (P < 0.05). Preoperative serum magnesium levels were significantly lower in Group B (P < 0.001). Conclusion: Patients who had received neoadjuvant chemotherapy had a delayed onset, shorter duration of action, and faster recovery for cisatracurium. Although preoperative magnesium levels were lower in Group B, it was found to be an independent predictor rather than a mediator of these effects." @default.
- W4382238369 created "2023-06-28" @default.
- W4382238369 creator A5017033401 @default.
- W4382238369 creator A5076415613 @default.
- W4382238369 date "2022-10-04" @default.
- W4382238369 modified "2023-09-25" @default.
- W4382238369 title "Neuromuscular blockade characteristics of cisatracurium in patients receiving chemotherapy" @default.
- W4382238369 doi "https://doi.org/10.4103/joacp.joacp_104_22" @default.
- W4382238369 hasPublicationYear "2022" @default.
- W4382238369 type Work @default.
- W4382238369 citedByCount "0" @default.
- W4382238369 crossrefType "journal-article" @default.
- W4382238369 hasAuthorship W4382238369A5017033401 @default.
- W4382238369 hasAuthorship W4382238369A5076415613 @default.
- W4382238369 hasBestOaLocation W43822383691 @default.
- W4382238369 hasConcept C121608353 @default.
- W4382238369 hasConcept C126322002 @default.
- W4382238369 hasConcept C141071460 @default.
- W4382238369 hasConcept C2776694085 @default.
- W4382238369 hasConcept C2776755627 @default.
- W4382238369 hasConcept C2777511904 @default.
- W4382238369 hasConcept C2778931672 @default.
- W4382238369 hasConcept C2781184374 @default.
- W4382238369 hasConcept C2909465803 @default.
- W4382238369 hasConcept C3020341438 @default.
- W4382238369 hasConcept C31174226 @default.
- W4382238369 hasConcept C42219234 @default.
- W4382238369 hasConcept C530470458 @default.
- W4382238369 hasConcept C71924100 @default.
- W4382238369 hasConceptScore W4382238369C121608353 @default.
- W4382238369 hasConceptScore W4382238369C126322002 @default.
- W4382238369 hasConceptScore W4382238369C141071460 @default.
- W4382238369 hasConceptScore W4382238369C2776694085 @default.
- W4382238369 hasConceptScore W4382238369C2776755627 @default.
- W4382238369 hasConceptScore W4382238369C2777511904 @default.
- W4382238369 hasConceptScore W4382238369C2778931672 @default.
- W4382238369 hasConceptScore W4382238369C2781184374 @default.
- W4382238369 hasConceptScore W4382238369C2909465803 @default.
- W4382238369 hasConceptScore W4382238369C3020341438 @default.
- W4382238369 hasConceptScore W4382238369C31174226 @default.
- W4382238369 hasConceptScore W4382238369C42219234 @default.
- W4382238369 hasConceptScore W4382238369C530470458 @default.
- W4382238369 hasConceptScore W4382238369C71924100 @default.
- W4382238369 hasLocation W43822383691 @default.
- W4382238369 hasOpenAccess W4382238369 @default.
- W4382238369 hasPrimaryLocation W43822383691 @default.
- W4382238369 hasRelatedWork W1995421842 @default.
- W4382238369 hasRelatedWork W1996626710 @default.
- W4382238369 hasRelatedWork W2002865831 @default.
- W4382238369 hasRelatedWork W2005033785 @default.
- W4382238369 hasRelatedWork W2006281927 @default.
- W4382238369 hasRelatedWork W2015090983 @default.
- W4382238369 hasRelatedWork W2074666562 @default.
- W4382238369 hasRelatedWork W2080835848 @default.
- W4382238369 hasRelatedWork W2356897053 @default.
- W4382238369 hasRelatedWork W2402957060 @default.
- W4382238369 hasVolume "Publish Ahead of Print" @default.
- W4382238369 isParatext "false" @default.
- W4382238369 isRetracted "false" @default.
- W4382238369 workType "article" @default.