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- W4382241803 abstract "Nine people with cystic fibrosis (pwCF) were found to have isolated elevations in serum total bilirubin after starting elexacaftor/tezacaftor/ivacaftor (ETI) that were associated with Gilbert’s Syndrome. In longitudinal examination, total bilirubin levels increased substantially after initiation of ETI without elevations in liver transaminases in those with this syndrome. Because elevated bilirubin levels in Gilbert’s Syndrome are benign, ETI was able to be continued in these individuals. Genetic testing for this relatively common syndrome should be strongly considered for pwCF experiencing isolated hyperbilirubinemia after starting ETI, since appropriate diagnosis may help pwCF avoid unnecessary interruption in this therapy with significant health benefits in CF." @default.
- W4382241803 created "2023-06-28" @default.
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- W4382241803 date "2023-06-27" @default.
- W4382241803 modified "2023-10-16" @default.
- W4382241803 title "Gilbert’s Syndrome Leads to Elevated Bilirubin after Initiation of Elexacaftor/Tezacaftor/Ivacaftor in People with Cystic Fibrosis" @default.
- W4382241803 doi "https://doi.org/10.22541/au.168787808.82841587/v1" @default.
- W4382241803 hasPublicationYear "2023" @default.
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