Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382243043> ?p ?o ?g. }
- W4382243043 abstract "Dacryodes edulis is a plant that belongs to the Burseraceae family. It is widely used traditionally alone or in association with other plants in Cameroonian folk medicine to cure wounds, fever, headaches, and malaria. The aim of this work was to investigate the leaves and stem bark of D. edulis with an emphasis on the antiplasmodial and cytotoxic effects of extracts, fractions, and isolated compounds.Extracts, fractions, and some isolated compounds were subjected to antiplasmodial activity screening in vitro against chloroquine-sensitive 3D7 and multidrug resistant Dd2 strains of Plasmodium falciparum using a SyBr Green fluorescence-based assay. The cytotoxicity of active extracts, fractions, and compounds was tested against mammalian Raw cell lines using an in vitro resazurin-based viability assay. The structures of the compounds were determined based on their NMR and MS data. The in vivo toxicity using female BALB/c mice was performed on the most active extract according to the protocol of OECD (2002), guideline 423.The hydroethanolic extract from the leaves of D. edulis displayed good antiplasmodial activity with IC50 values of 3.10 and 3.56 μg/mL respectively on sensitive (3D7) and multiresistant (Dd2) strains of P. falciparum. Of the sixteen compounds isolated, 3,3',4-tri-O-methylellagic acid (4) exhibited the highest antiplasmodial activity against PfDd2 strains with an IC50 value of 0.63 μg/mL. All extracts, fractions, and isolated compounds demonstrated no cytotoxicity against Raw cell lines with CC50 > 250 μg/mL. In addition, the most active extract on both strains of P. falciparum was nontoxic in vivo, with a LD50 greater than 2000 and 5000 mg/kg. A phytochemical investigation of the stem bark and leaves of D. edulis afforded sixteen compounds, including two xanthones (1-2), three ellagic acid derivatives (3-5), one phenolic compound (6), one depside (7), one triglyceride (8), one auranthiamide acetate (9), one gallic acid derivative (10), four triterpenoids (11-14), and two steroids (15-16). Compounds 1, 2, 5, 7, 8, and 9 were herein reported for the first time from the Burseraceae family.This work highlights the good in vitro antiplasmodial potency of the hydroethanolic extract of the leaves of this plant and that of two isolated constituents (3,3',4-tri-O-methylellagic acid and ethylgallate) from the plant. These biological results support the use of D. edulis in traditional medicine against malaria." @default.
- W4382243043 created "2023-06-28" @default.
- W4382243043 creator A5006409222 @default.
- W4382243043 creator A5012443689 @default.
- W4382243043 creator A5029983639 @default.
- W4382243043 creator A5031900213 @default.
- W4382243043 creator A5034135483 @default.
- W4382243043 creator A5042838349 @default.
- W4382243043 creator A5061194802 @default.
- W4382243043 creator A5078397530 @default.
- W4382243043 creator A5078575294 @default.
- W4382243043 creator A5079966506 @default.
- W4382243043 date "2023-06-27" @default.
- W4382243043 modified "2023-10-08" @default.
- W4382243043 title "In vitro antiplasmodial activity and toxicological profile of extracts, fractions and chemical constituents of leaves and stem bark from Dacryodes edulis (Burseraceae)" @default.
- W4382243043 cites W1550220183 @default.
- W4382243043 cites W1907426501 @default.
- W4382243043 cites W1967682064 @default.
- W4382243043 cites W1986581779 @default.
- W4382243043 cites W2020251171 @default.
- W4382243043 cites W2022786242 @default.
- W4382243043 cites W2046166955 @default.
- W4382243043 cites W2055573265 @default.
- W4382243043 cites W2063599946 @default.
- W4382243043 cites W2087215482 @default.
- W4382243043 cites W2091994604 @default.
- W4382243043 cites W2114818342 @default.
- W4382243043 cites W2124074278 @default.
- W4382243043 cites W2150518783 @default.
- W4382243043 cites W2174562327 @default.
- W4382243043 cites W2476485832 @default.
- W4382243043 cites W2524182728 @default.
- W4382243043 cites W2579179945 @default.
- W4382243043 cites W3018391065 @default.
- W4382243043 cites W3047879827 @default.
- W4382243043 cites W3176261984 @default.
- W4382243043 cites W4240644295 @default.
- W4382243043 cites W4247089587 @default.
- W4382243043 cites W4313192418 @default.
- W4382243043 doi "https://doi.org/10.1186/s12906-023-03957-2" @default.
- W4382243043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37370061" @default.
- W4382243043 hasPublicationYear "2023" @default.
- W4382243043 type Work @default.
- W4382243043 citedByCount "0" @default.
- W4382243043 crossrefType "journal-article" @default.
- W4382243043 hasAuthorship W4382243043A5006409222 @default.
- W4382243043 hasAuthorship W4382243043A5012443689 @default.
- W4382243043 hasAuthorship W4382243043A5029983639 @default.
- W4382243043 hasAuthorship W4382243043A5031900213 @default.
- W4382243043 hasAuthorship W4382243043A5034135483 @default.
- W4382243043 hasAuthorship W4382243043A5042838349 @default.
- W4382243043 hasAuthorship W4382243043A5061194802 @default.
- W4382243043 hasAuthorship W4382243043A5078397530 @default.
- W4382243043 hasAuthorship W4382243043A5078575294 @default.
- W4382243043 hasAuthorship W4382243043A5079966506 @default.
- W4382243043 hasBestOaLocation W43822430431 @default.
- W4382243043 hasConcept C109316439 @default.
- W4382243043 hasConcept C150903083 @default.
- W4382243043 hasConcept C185592680 @default.
- W4382243043 hasConcept C202751555 @default.
- W4382243043 hasConcept C203014093 @default.
- W4382243043 hasConcept C207001950 @default.
- W4382243043 hasConcept C2777752497 @default.
- W4382243043 hasConcept C2778048844 @default.
- W4382243043 hasConcept C2778371730 @default.
- W4382243043 hasConcept C2780096663 @default.
- W4382243043 hasConcept C2780156252 @default.
- W4382243043 hasConcept C55493867 @default.
- W4382243043 hasConcept C556039675 @default.
- W4382243043 hasConcept C71924100 @default.
- W4382243043 hasConcept C86803240 @default.
- W4382243043 hasConceptScore W4382243043C109316439 @default.
- W4382243043 hasConceptScore W4382243043C150903083 @default.
- W4382243043 hasConceptScore W4382243043C185592680 @default.
- W4382243043 hasConceptScore W4382243043C202751555 @default.
- W4382243043 hasConceptScore W4382243043C203014093 @default.
- W4382243043 hasConceptScore W4382243043C207001950 @default.
- W4382243043 hasConceptScore W4382243043C2777752497 @default.
- W4382243043 hasConceptScore W4382243043C2778048844 @default.
- W4382243043 hasConceptScore W4382243043C2778371730 @default.
- W4382243043 hasConceptScore W4382243043C2780096663 @default.
- W4382243043 hasConceptScore W4382243043C2780156252 @default.
- W4382243043 hasConceptScore W4382243043C55493867 @default.
- W4382243043 hasConceptScore W4382243043C556039675 @default.
- W4382243043 hasConceptScore W4382243043C71924100 @default.
- W4382243043 hasConceptScore W4382243043C86803240 @default.
- W4382243043 hasIssue "1" @default.
- W4382243043 hasLocation W43822430431 @default.
- W4382243043 hasLocation W43822430432 @default.
- W4382243043 hasOpenAccess W4382243043 @default.
- W4382243043 hasPrimaryLocation W43822430431 @default.
- W4382243043 hasRelatedWork W1592261125 @default.
- W4382243043 hasRelatedWork W1919374467 @default.
- W4382243043 hasRelatedWork W1982027601 @default.
- W4382243043 hasRelatedWork W2024927426 @default.
- W4382243043 hasRelatedWork W2060010466 @default.
- W4382243043 hasRelatedWork W2093492325 @default.
- W4382243043 hasRelatedWork W2411863804 @default.
- W4382243043 hasRelatedWork W2436912489 @default.
- W4382243043 hasRelatedWork W2464301138 @default.