Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382279238> ?p ?o ?g. }
- W4382279238 abstract "Abstract In situ hydrogelation of injectable precursors upon biological stimulus is relevant to generate hydrogels under mild conditions and, potentially, at a biological side of interest. Here, it is shown that hydrolytic enzymes can be used to initiate the formation of covalent hydrogel networks, realizing a cleavage‐leading‐to‐gelation strategy. For this purpose, a two‐component system is used, consisting of a 4‐arm polyethylene glycol‐thiodepsipeptide conjugate, PEG4TDP o containing the matrix metalloproteinases MMP‐2‐ and MMP‐9‐cleavable Ac‐Pro‐Leu‐Gly#SLeu‐Leu‐Gly‐ thiodepsipeptide sequence releasing a thiol upon hydrolysis, and a maleimide functionalized 4‐armed PEG (PEG4MAL). PEG4TDP o is synthesized in a PEG‐functionalization protocol involving convergent and divergent synthetic steps without the need for rigorous purification procedures. In a fluorometric assay, it is shown that the construct is in fact cleaved by both investigated MMPs. PEG4TDP o in the presence of 10 wt.% PEG4MAL formed hydrogels upon addition of MMP‐2 or ‐9 with average gelation times of 28 and 40 min, respectively, as is investigated by rheology. The much faster gelation times compared to the enzyme‐free system showed the specific input of the enzymatic reactions. The MMP‐assisted activation and crosslinking strategy can potentially become useful by targeting tissues showing an increased expression of MMPs, such as cancers, or to detect MMPs." @default.
- W4382279238 created "2023-06-28" @default.
- W4382279238 creator A5020550953 @default.
- W4382279238 creator A5037426480 @default.
- W4382279238 creator A5063227740 @default.
- W4382279238 creator A5068998923 @default.
- W4382279238 date "2023-06-27" @default.
- W4382279238 modified "2023-10-17" @default.
- W4382279238 title "A 4‐Arm PEG‐Thiodepsipeptide Precursor Enables Gelatinase‐Promoted Hydrogel Formation" @default.
- W4382279238 cites W1787366775 @default.
- W4382279238 cites W1970742175 @default.
- W4382279238 cites W1975208457 @default.
- W4382279238 cites W1980792218 @default.
- W4382279238 cites W1983803268 @default.
- W4382279238 cites W1984490099 @default.
- W4382279238 cites W1986968030 @default.
- W4382279238 cites W1992955004 @default.
- W4382279238 cites W1994694542 @default.
- W4382279238 cites W2004145475 @default.
- W4382279238 cites W2006628284 @default.
- W4382279238 cites W2011046820 @default.
- W4382279238 cites W2012077906 @default.
- W4382279238 cites W2013298034 @default.
- W4382279238 cites W2015589806 @default.
- W4382279238 cites W2018282847 @default.
- W4382279238 cites W2022743857 @default.
- W4382279238 cites W2023412782 @default.
- W4382279238 cites W2027189950 @default.
- W4382279238 cites W2028289489 @default.
- W4382279238 cites W2030005835 @default.
- W4382279238 cites W2031502774 @default.
- W4382279238 cites W2034560811 @default.
- W4382279238 cites W2037660784 @default.
- W4382279238 cites W2041111618 @default.
- W4382279238 cites W2043249135 @default.
- W4382279238 cites W2043551626 @default.
- W4382279238 cites W2045049033 @default.
- W4382279238 cites W2051862132 @default.
- W4382279238 cites W2054781768 @default.
- W4382279238 cites W2067484586 @default.
- W4382279238 cites W2071102379 @default.
- W4382279238 cites W2072027664 @default.
- W4382279238 cites W2074363870 @default.
- W4382279238 cites W2077113770 @default.
- W4382279238 cites W2078386086 @default.
- W4382279238 cites W2097033861 @default.
- W4382279238 cites W2097103130 @default.
- W4382279238 cites W2117481374 @default.
- W4382279238 cites W2150098028 @default.
- W4382279238 cites W2153940157 @default.
- W4382279238 cites W2163922123 @default.
- W4382279238 cites W2168643487 @default.
- W4382279238 cites W2169430024 @default.
- W4382279238 cites W2417730386 @default.
- W4382279238 cites W2419305637 @default.
- W4382279238 cites W2614371588 @default.
- W4382279238 cites W2766832099 @default.
- W4382279238 cites W2769851065 @default.
- W4382279238 cites W2887700508 @default.
- W4382279238 cites W2904882497 @default.
- W4382279238 cites W2908965752 @default.
- W4382279238 cites W2912051674 @default.
- W4382279238 cites W2914328235 @default.
- W4382279238 cites W2951050916 @default.
- W4382279238 cites W2967716953 @default.
- W4382279238 cites W3004088839 @default.
- W4382279238 cites W3009647487 @default.
- W4382279238 cites W3039707712 @default.
- W4382279238 cites W3137427772 @default.
- W4382279238 cites W3178059932 @default.
- W4382279238 cites W4214828783 @default.
- W4382279238 cites W4254177951 @default.
- W4382279238 doi "https://doi.org/10.1002/mame.202300146" @default.
- W4382279238 hasPublicationYear "2023" @default.
- W4382279238 type Work @default.
- W4382279238 citedByCount "0" @default.
- W4382279238 crossrefType "journal-article" @default.
- W4382279238 hasAuthorship W4382279238A5020550953 @default.
- W4382279238 hasAuthorship W4382279238A5037426480 @default.
- W4382279238 hasAuthorship W4382279238A5063227740 @default.
- W4382279238 hasAuthorship W4382279238A5068998923 @default.
- W4382279238 hasBestOaLocation W43822792381 @default.
- W4382279238 hasConcept C10138342 @default.
- W4382279238 hasConcept C108586683 @default.
- W4382279238 hasConcept C109523444 @default.
- W4382279238 hasConcept C115537861 @default.
- W4382279238 hasConcept C134306372 @default.
- W4382279238 hasConcept C147789679 @default.
- W4382279238 hasConcept C162324750 @default.
- W4382279238 hasConcept C178790620 @default.
- W4382279238 hasConcept C180577832 @default.
- W4382279238 hasConcept C185592680 @default.
- W4382279238 hasConcept C188027245 @default.
- W4382279238 hasConcept C192562407 @default.
- W4382279238 hasConcept C197336794 @default.
- W4382279238 hasConcept C21951064 @default.
- W4382279238 hasConcept C2776232661 @default.
- W4382279238 hasConcept C2776964284 @default.
- W4382279238 hasConcept C2780105360 @default.
- W4382279238 hasConcept C33923547 @default.