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- W4382343938 abstract "Importance Spanish-speaking participants are underrepresented in clinical trials, limiting study generalizability and contributing to ongoing health inequity. The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) trial intentionally included Spanish-speaking participants. Objective To describe trial participation and compare clinical and patient-reported outcomes among Spanish-speaking and English-speaking participants with acute appendicitis randomized to antibiotics. Design, Setting, and Participants This study is a secondary analysis of the CODA trial, a pragmatic randomized trial comparing antibiotic therapy with appendectomy in adult patients with imaging-confirmed appendicitis enrolled at 25 centers across the US from May 1, 2016, to February 28, 2020. The trial was conducted in English and Spanish. All 776 participants randomized to antibiotics are included in this analysis. The data were analyzed from November 15, 2021, through August 24, 2022. Intervention Randomization to a 10-day course of antibiotics or appendectomy. Main Outcomes and Measures Trial participation, European Quality of Life–5 Dimensions (EQ-5D) questionnaire scores (higher scores indicating a better health status), rate of appendectomy, treatment satisfaction, decisional regret, and days of work missed. Outcomes are also reported for a subset of participants that were recruited from the 5 sites with a large proportion of Spanish-speaking participants. Results Among eligible patients 476 of 1050 Spanish speakers (45%) and 1076 of 3982 of English speakers (27%) consented, comprising the 1552 participants who underwent 1:1 randomization (mean age, 38.0 years; 976 male [63%]). Of the 776 participants randomized to antibiotics, 238 were Spanish speaking (31%). Among Spanish speakers randomized to antibiotics, the rate of appendectomy was 22% (95% CI, 17%-28%) at 30 days and 45% (95% CI, 38%-52%) at 1 year, while in English speakers, these rates were 20% (95% CI, 16%-23%) at 30 days and 42% (95% CI 38%-47%) at 1 year. Mean EQ-5D scores were 0.93 (95% CI, 0.92-0.95) among Spanish speakers and 0.92 (95% CI, 0.91-0.93) among English speakers. Symptom resolution at 30 days was reported by 68% (95% CI, 61%-74%) of Spanish speakers and 69% (95% CI, 64%-73%) of English speakers. Spanish speakers missed 6.69 (95% CI, 5.51-7.87) days of work on average, while English speakers missed 3.76 (95% CI, 3.20-4.32) days. Presentation to the emergency department or urgent care, hospitalization, treatment dissatisfaction, and decisional regret were low for both groups. Conclusions and Relevance A high proportion of Spanish speakers participated in the CODA trial. Clinical and most patient-reported outcomes were similar for English- and Spanish-speaking participants treated with antibiotics. Spanish speakers reported more days of missed work. Trial Registration ClinicalTrials.gov Identifier: NCT02800785" @default.
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- W4382343938 date "2023-09-01" @default.
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- W4382343938 title "Trial Participation and Outcomes Among English-Speaking and Spanish-Speaking Patients With Appendicitis Randomized to Antibiotics" @default.
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- W4382343938 cites W2070523110 @default.
- W4382343938 cites W2073946121 @default.
- W4382343938 cites W2084279866 @default.
- W4382343938 cites W2115411456 @default.
- W4382343938 cites W2128681611 @default.
- W4382343938 cites W2131460081 @default.
- W4382343938 cites W2148844447 @default.
- W4382343938 cites W2148912141 @default.
- W4382343938 cites W2153836018 @default.
- W4382343938 cites W2167096525 @default.
- W4382343938 cites W2213788212 @default.
- W4382343938 cites W2303436610 @default.
- W4382343938 cites W2501447780 @default.
- W4382343938 cites W2541304379 @default.
- W4382343938 cites W2566576468 @default.
- W4382343938 cites W2604259122 @default.
- W4382343938 cites W2604748569 @default.
- W4382343938 cites W2768035605 @default.
- W4382343938 cites W2768711575 @default.
- W4382343938 cites W2803555760 @default.
- W4382343938 cites W2897352319 @default.
- W4382343938 cites W2911145493 @default.
- W4382343938 cites W2940303735 @default.
- W4382343938 cites W3007080458 @default.
- W4382343938 cites W3009137536 @default.
- W4382343938 cites W3036649375 @default.
- W4382343938 cites W3089918790 @default.
- W4382343938 cites W3199100532 @default.
- W4382343938 cites W4223539866 @default.
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- W4382343938 cites W4244185407 @default.
- W4382343938 cites W4245379858 @default.
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- W4382343938 doi "https://doi.org/10.1001/jamasurg.2023.2277" @default.
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