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- W4382344235 endingPage "948" @default.
- W4382344235 startingPage "939" @default.
- W4382344235 abstract "Introduction Chronic sinusitis with nasal polyposis (CRSwNP) is a common heterogeneous disease that mainly manifests as chronic inflammation of the sinus mucosa. The effect of conventional treatments for CRSwNP, such as oral corticosteroids, intranasal corticosteroids (INCS) and polypectomy, is not always obvious, and postoperative recurrence is common in some CRSwNP patients. In recent years, some biologics have been shown to be very effective in treating refractory CRSwNP, of which dupilumab has attracted much attention as the first monoclonal drug approved to treat nasal polyps.Areas covered In this review, we discuss the research status of dupilumab in treatment of CRSwNP and how dupilumab differs from other treatment methods.Expert opinion The European Union and United States have approved dupilumab as the first biological agent for treatment of CRSwNP. Dupilumab can improve symptoms of nasal congestion or obstruction, nasal secretion, and olfactory loss in patients with CRSwNP. It can also improve a patient’s health-related quality of life (HR-QoL) and reduce the need for systemic corticosteroids and nasal polyp surgery. While subcutaneous injection of dupilumab is a novel method for treating CRSwNP, it is still necessary to reasonably evaluate which patients might benefit most from biological therapy." @default.
- W4382344235 created "2023-06-29" @default.
- W4382344235 creator A5039805412 @default.
- W4382344235 creator A5040300494 @default.
- W4382344235 creator A5055885642 @default.
- W4382344235 creator A5058617990 @default.
- W4382344235 creator A5059567337 @default.
- W4382344235 creator A5083588367 @default.
- W4382344235 date "2023-07-03" @default.
- W4382344235 modified "2023-09-28" @default.
- W4382344235 title "Dupilumab in chronic rhinosinusitis with nasal polyposis: current status, challenges, and future perspectives" @default.
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