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- W4382344694 endingPage "8381" @default.
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- W4382344694 abstract "Estrogen receptor alpha (ERα) is a well-established therapeutic target for the treatment of ER-positive (ER+) breast cancers. Despite the tremendous successes achieved with tamoxifen, a selective ER modulator, and aromatase inhibitors (AIs), resistance to these therapies is a major clinical problem. Therefore, induced protein degradation and covalent inhibition have been pursued as new therapeutic approaches to target ERα. This Perspective summarizes recent progress in the discovery and development of oral selective ER degraders (SERDs), complete estrogen receptor antagonists (CERANs), selective estrogen receptor covalent antagonists (SERCAs), and proteolysis targeting chimera (PROTAC) ER degraders. We focus on those compounds which have been advanced into clinical development." @default.
- W4382344694 created "2023-06-29" @default.
- W4382344694 creator A5013173126 @default.
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- W4382344694 creator A5052071953 @default.
- W4382344694 creator A5073754378 @default.
- W4382344694 date "2023-06-28" @default.
- W4382344694 modified "2023-09-30" @default.
- W4382344694 title "Targeting the Estrogen Receptor for the Treatment of Breast Cancer: Recent Advances and Challenges" @default.
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