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- W4382345083 abstract "Filamin C (FLNC), a large dimeric actin-binding protein in muscle cells, plays a critical role in transmitting force in the cytoskeleton and that between membrane receptors and the cytoskeleton. It performs crucial mechanosensing and downstream mechanotransduction functions via force-dependent interactions with signaling proteins. Mutations in FLNC have been linked to muscle and heart diseases. The mechanical responses of the force-bearing elements in FLNC have not been determined. This study investigated the mechanical responses of FLNC domains and their dimerization interface using magnetic tweezers. Results showed high stability of the N-terminal domains in the rod-1 segment but significant changes in the rod-2 domains in response to forces of a few piconewtons (pN). The dimerization interface, formed by the R24 domain, has a lifetime of seconds to tens of seconds at pN forces, and it dissociates within 1 s at forces greater than 14 pN. The findings suggest the FLNC dimerization interface provides sufficient mechanical stability that enables force-dependent structural changes in rod-2 domains for signaling protein binding and maintains structural integrity of the rod-1 domains." @default.
- W4382345083 created "2023-06-29" @default.
- W4382345083 creator A5029928652 @default.
- W4382345083 creator A5081786893 @default.
- W4382345083 date "2023-06-27" @default.
- W4382345083 modified "2023-10-17" @default.
- W4382345083 title "Force-Dependent Structural Changes of Filamin C Rod Domains Regulated by Filamin C Dimer" @default.
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- W4382345083 doi "https://doi.org/10.1021/jacs.3c02303" @default.
- W4382345083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37369984" @default.
- W4382345083 hasPublicationYear "2023" @default.
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