FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382362893> ?p ?o ?g. }

• W4382362893 abstract "Abstract Background Diabetic foot ulcer (DFU) is a common chronic and serious complication that impairs patients' quality of life. The relationship between ferroptosis and complications of diabetes has attracted much attention in recent years. Here, this study aims to apply the gene expression profile of dermal lymphatic endothelial cells (DLECs) to build a ceRNA network and explore potential ferroptosis-related biomarkers and pathways related to the molecular mechanism of DFU. Methods The GSE38396 dataset from the Gene Expression Omnibus (GEO) collection was utilized to analyze differentially expressed genes (DEGs) in DLECs of DFU. The protein-protein interaction (PPI) network and enrichment analysis of DEGs were carried out. Subsequently, we performed a comprehensive analysis of hub genes identified from the PPI. To yield the key ferroptosis-related genes strongly associated with DLECs of DFU, we integrated multiple datasets and the least absolute shrinkage and selection operator (LASSO) model, which was validated with external datasets (GSE147890) via receiver operating characteristic (ROC) curves. Meanwhile, GSE147890 and GSE29221 were utilized as external datasets to validate the efficiency of key genes as potential biomarkers for DFU. Results The 149 DEGs in DLECs of DFU were obtained using the GSE38396 dataset. Gene Ontology (GO) analysis showed that the collagen-containing extracellular matrix was primarily enriched. The HIF-1 signaling pathway was considered the key pathway by the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. We obtained 12 hub genes from the subnetwork in the PPI network and identified EGFR as a key ferroptosis-related gene by the LASSO model, which had a high AUC value (0.76). In addition, two external datasets validated EGFR with high efficiency (GSE147890: 0.67, GSE29221: 0.72). Ultimately, we constructed a ceRNA network consisting of 5 lncRNAs, 2 miRNAs, and 1 mRNA around EGFR. Conclusions As a key ferroptosis-related gene related to DLECs of DFU, EGFR may be regulated by upstream lncRNA, which in turn affects the activity of the HIF-1 pathway and affects the occurrence and development of DFU. Thus, the results of this study can provide a certain direction and basis for follow-up studies of DFU and provide new insights into the prevention and treatment of DFU." @default.
• W4382362893 created "2023-06-29" @default.
• W4382362893 creator A5001920272 @default.
• W4382362893 creator A5005647981 @default.
• W4382362893 creator A5007239313 @default.
• W4382362893 creator A5009988205 @default.
• W4382362893 creator A5021541475 @default.
• W4382362893 creator A5031394551 @default.
• W4382362893 creator A5034503229 @default.
• W4382362893 creator A5046270698 @default.
• W4382362893 creator A5046852822 @default.
• W4382362893 creator A5049078993 @default.
• W4382362893 creator A5062619881 @default.
• W4382362893 creator A5085122646 @default.
• W4382362893 creator A5087592842 @default.
• W4382362893 date "2023-06-28" @default.
• W4382362893 modified "2023-09-26" @default.
• W4382362893 title "Machine learning revealed novel ferroptosis-related genes and construction ceRNA network in dermal lymphatic endothelial cells of diabetic foot ulcer" @default.
• W4382362893 cites W1847744149 @default.
• W4382362893 cites W1997183854 @default.
• W4382362893 cites W2156635057 @default.
• W4382362893 cites W2792195475 @default.
• W4382362893 cites W2900730055 @default.
• W4382362893 cites W2908907717 @default.
• W4382362893 cites W2939275762 @default.
• W4382362893 cites W2946257321 @default.
• W4382362893 cites W2958836234 @default.
• W4382362893 cites W2974143440 @default.
• W4382362893 cites W2994511180 @default.
• W4382362893 cites W2998745948 @default.
• W4382362893 cites W3006293845 @default.
• W4382362893 cites W3013579324 @default.
• W4382362893 cites W3015227758 @default.
• W4382362893 cites W3015781843 @default.
• W4382362893 cites W3043699269 @default.
• W4382362893 cites W3044864655 @default.
• W4382362893 cites W3044899207 @default.
• W4382362893 cites W3089643973 @default.
• W4382362893 cites W3108408672 @default.
• W4382362893 cites W3113019470 @default.
• W4382362893 cites W3129858746 @default.
• W4382362893 cites W3138498842 @default.
• W4382362893 cites W3175656652 @default.
• W4382362893 cites W4206259166 @default.
• W4382362893 cites W4211146151 @default.
• W4382362893 cites W4281568209 @default.
• W4382362893 doi "https://doi.org/10.21203/rs.3.rs-3095868/v1" @default.
• W4382362893 hasPublicationYear "2023" @default.
• W4382362893 type Work @default.
• W4382362893 citedByCount "0" @default.
• W4382362893 crossrefType "posted-content" @default.
• W4382362893 hasAuthorship W4382362893A5001920272 @default.
• W4382362893 hasAuthorship W4382362893A5005647981 @default.
• W4382362893 hasAuthorship W4382362893A5007239313 @default.
• W4382362893 hasAuthorship W4382362893A5009988205 @default.
• W4382362893 hasAuthorship W4382362893A5021541475 @default.
• W4382362893 hasAuthorship W4382362893A5031394551 @default.
• W4382362893 hasAuthorship W4382362893A5034503229 @default.
• W4382362893 hasAuthorship W4382362893A5046270698 @default.
• W4382362893 hasAuthorship W4382362893A5046852822 @default.
• W4382362893 hasAuthorship W4382362893A5049078993 @default.
• W4382362893 hasAuthorship W4382362893A5062619881 @default.
• W4382362893 hasAuthorship W4382362893A5085122646 @default.
• W4382362893 hasAuthorship W4382362893A5087592842 @default.
• W4382362893 hasBestOaLocation W43823628931 @default.
• W4382362893 hasConcept C104317684 @default.
• W4382362893 hasConcept C136764020 @default.
• W4382362893 hasConcept C150194340 @default.
• W4382362893 hasConcept C152724338 @default.
• W4382362893 hasConcept C186836561 @default.
• W4382362893 hasConcept C2987395477 @default.
• W4382362893 hasConcept C37616216 @default.
• W4382362893 hasConcept C41008148 @default.
• W4382362893 hasConcept C54355233 @default.
• W4382362893 hasConcept C60644358 @default.
• W4382362893 hasConcept C70721500 @default.
• W4382362893 hasConcept C8415881 @default.
• W4382362893 hasConcept C86803240 @default.
• W4382362893 hasConceptScore W4382362893C104317684 @default.
• W4382362893 hasConceptScore W4382362893C136764020 @default.
• W4382362893 hasConceptScore W4382362893C150194340 @default.
• W4382362893 hasConceptScore W4382362893C152724338 @default.
• W4382362893 hasConceptScore W4382362893C186836561 @default.
• W4382362893 hasConceptScore W4382362893C2987395477 @default.
• W4382362893 hasConceptScore W4382362893C37616216 @default.
• W4382362893 hasConceptScore W4382362893C41008148 @default.
• W4382362893 hasConceptScore W4382362893C54355233 @default.
• W4382362893 hasConceptScore W4382362893C60644358 @default.
• W4382362893 hasConceptScore W4382362893C70721500 @default.
• W4382362893 hasConceptScore W4382362893C8415881 @default.
• W4382362893 hasConceptScore W4382362893C86803240 @default.
• W4382362893 hasLocation W43823628931 @default.
• W4382362893 hasOpenAccess W4382362893 @default.
• W4382362893 hasPrimaryLocation W43823628931 @default.
• W4382362893 hasRelatedWork W2001670874 @default.
• W4382362893 hasRelatedWork W2002714666 @default.
• W4382362893 hasRelatedWork W2056362778 @default.
• W4382362893 hasRelatedWork W2302239767 @default.
• W4382362893 hasRelatedWork W2579521551 @default.
• W4382362893 hasRelatedWork W2801630139 @default.

• next