Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382362904> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4382362904 abstract "Abstract Background Long non-coding RNAs (LncRNAs) have been found to be a potential prognostic factor for cancers, including hepatocellular carcinoma (HCC). Some LncRNAs have been confirmed as potential indicators to quantify genomic instability (GI). Nevertheless, GI-LncRNAs remains largely unexplored. This study establishes a genomic instability-derived LncRNA signature (GILncSig) that can predict the prognosis of HCC patients. Methods Identifying the GI-LncRNAs by combining LncRNA expression and somatic mutation profiles. Next, GI-LncRNAs were analyzed for functional enrichment. GILncSig was established in the training set by Cox regression analysis, and its predictive ability was verified in testing set and TCGA set. In addition, we explored the effects of GILncSig and TP53 on the prognosis. Results A total of 88 GI-LncRNAs were found, and functional enrichment analysis showed that their functions were mainly involved in small molecule metabolism and GI. GILncSig was constructed by 5 LncRNAs (MIR210HG, AC016735.1, AC116351.1, AC010643.1, LUCAT1). In the training set, the prognosis of high-risk patients was significantly worse than that of low-risk patients, and similar results were verified in the testing set and TCGA set. Multivariate Cox regression analysis and stratified analysis confirmed that GILncSig could be used as an independent prognostic factor The ROC curve analysis of GILncSig showed that its AUC (0.773) was higher than the two LncRNA signatures published recently. Furthermore, GILncSig may have a better predictive performance than TP53 mutation status alone. Conclusion We established a GILncSig that can predict the prognosis of HCC patients, which can help to guide the prognostic evaluation and treatment decisions." @default.
- W4382362904 created "2023-06-29" @default.
- W4382362904 creator A5005295988 @default.
- W4382362904 creator A5015523140 @default.
- W4382362904 creator A5017220291 @default.
- W4382362904 creator A5036701001 @default.
- W4382362904 creator A5047176714 @default.
- W4382362904 creator A5075442335 @default.
- W4382362904 date "2023-06-28" @default.
- W4382362904 modified "2023-09-25" @default.
- W4382362904 title "Construction and validation of somatic mutation-derived LncRNA signatures of genomic instability to predict prognosis of hepatocellular carcinoma" @default.
- W4382362904 doi "https://doi.org/10.21203/rs.3.rs-3092494/v1" @default.
- W4382362904 hasPublicationYear "2023" @default.
- W4382362904 type Work @default.
- W4382362904 citedByCount "0" @default.
- W4382362904 crossrefType "posted-content" @default.
- W4382362904 hasAuthorship W4382362904A5005295988 @default.
- W4382362904 hasAuthorship W4382362904A5015523140 @default.
- W4382362904 hasAuthorship W4382362904A5017220291 @default.
- W4382362904 hasAuthorship W4382362904A5036701001 @default.
- W4382362904 hasAuthorship W4382362904A5047176714 @default.
- W4382362904 hasAuthorship W4382362904A5075442335 @default.
- W4382362904 hasBestOaLocation W43823629041 @default.
- W4382362904 hasConcept C104317684 @default.
- W4382362904 hasConcept C10515644 @default.
- W4382362904 hasConcept C126322002 @default.
- W4382362904 hasConcept C134305767 @default.
- W4382362904 hasConcept C13514818 @default.
- W4382362904 hasConcept C143425029 @default.
- W4382362904 hasConcept C143998085 @default.
- W4382362904 hasConcept C178169997 @default.
- W4382362904 hasConcept C2778019345 @default.
- W4382362904 hasConcept C38180746 @default.
- W4382362904 hasConcept C501734568 @default.
- W4382362904 hasConcept C50382708 @default.
- W4382362904 hasConcept C54355233 @default.
- W4382362904 hasConcept C552990157 @default.
- W4382362904 hasConcept C58471807 @default.
- W4382362904 hasConcept C70721500 @default.
- W4382362904 hasConcept C71924100 @default.
- W4382362904 hasConcept C86803240 @default.
- W4382362904 hasConceptScore W4382362904C104317684 @default.
- W4382362904 hasConceptScore W4382362904C10515644 @default.
- W4382362904 hasConceptScore W4382362904C126322002 @default.
- W4382362904 hasConceptScore W4382362904C134305767 @default.
- W4382362904 hasConceptScore W4382362904C13514818 @default.
- W4382362904 hasConceptScore W4382362904C143425029 @default.
- W4382362904 hasConceptScore W4382362904C143998085 @default.
- W4382362904 hasConceptScore W4382362904C178169997 @default.
- W4382362904 hasConceptScore W4382362904C2778019345 @default.
- W4382362904 hasConceptScore W4382362904C38180746 @default.
- W4382362904 hasConceptScore W4382362904C501734568 @default.
- W4382362904 hasConceptScore W4382362904C50382708 @default.
- W4382362904 hasConceptScore W4382362904C54355233 @default.
- W4382362904 hasConceptScore W4382362904C552990157 @default.
- W4382362904 hasConceptScore W4382362904C58471807 @default.
- W4382362904 hasConceptScore W4382362904C70721500 @default.
- W4382362904 hasConceptScore W4382362904C71924100 @default.
- W4382362904 hasConceptScore W4382362904C86803240 @default.
- W4382362904 hasLocation W43823629041 @default.
- W4382362904 hasOpenAccess W4382362904 @default.
- W4382362904 hasPrimaryLocation W43823629041 @default.
- W4382362904 hasRelatedWork W1992278374 @default.
- W4382362904 hasRelatedWork W205960099 @default.
- W4382362904 hasRelatedWork W2068083072 @default.
- W4382362904 hasRelatedWork W2237842930 @default.
- W4382362904 hasRelatedWork W2361700749 @default.
- W4382362904 hasRelatedWork W3034169103 @default.
- W4382362904 hasRelatedWork W3158644626 @default.
- W4382362904 hasRelatedWork W4205198487 @default.
- W4382362904 hasRelatedWork W4231405903 @default.
- W4382362904 hasRelatedWork W4323566107 @default.
- W4382362904 isParatext "false" @default.
- W4382362904 isRetracted "false" @default.
- W4382362904 workType "article" @default.