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- W4382363376 abstract "Abstract Circular RNAs (circRNAs) are a subtype of non-coding RNAs and contribute to the various central nervous system (CNS) diseases. However, microglia apoptosis which is regulated by circRNAs in major depressive disorder (MDD) is incompletely clear. Herein, we have shown that the circular RNA DYM (circDYM) binds to the transcription factor CEBPB, thereby releasing repression of CEBPB target gene ZC3H4 transcription. The result of our study provides new insights in function of circDYM to microglia apoptosis in depression. Taken together, we identify that circRNA drives neuroinflammation and serves as a new potential target for therapy of depression." @default.
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- W4382363376 date "2023-06-28" @default.
- W4382363376 modified "2023-10-14" @default.
- W4382363376 title "Mechanism of circDYM/CEBPB/ZC3H4 axis in LPS-induced Microglial Apoptosis" @default.
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- W4382363376 doi "https://doi.org/10.21203/rs.3.rs-3094444/v1" @default.
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