FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382364355> ?p ?o ?g. }

• W4382364355 endingPage "123088" @default.
• W4382364355 startingPage "123088" @default.
• W4382364355 abstract "Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative brain disorder with significant economic and societal impacts, whereas early AD diagnosis remains a considerable challenge. Here, a robust and convenient surface-enhanced Raman scattering (SERS) analysis platform was fabricated on a microarray chip to dissect the variation in serum composition for AD diagnosis, eliminating the invasive cerebrospinal fluid (CSF)-based and costly instrument-dependent diagnostic methods. AuNOs array prepared by self-assembly at liquid-liquid interface enabled the acquirement of SERS spectra with excellent reproducibility. Moreover, a finite-difference time-domain (FDTD) simulation suggested the significant plasmon hybridization generated by AuNOs aggregation, resulting in high signal-to-noise ratio SERS spectra. We established an AD mice model with Aβ1-40 induction followed by recording the serum SERS spectra at different stages. A multivariate analysis method of principal component analysis (PCA)-weighted representation-based k-nearest neighbor (WRKNN) was applied for the characteristics extraction to improve the classification performance, with an accuracy of over 95%, an AUC of over 90%, a sensitivity of over 80%, and a specificity of over 96.7%. The results of this study demonstrate the potential of SERS application as a diagnostic screening method, following further validation and optimization, which may open up new exciting opportunities for future biomedical applications." @default.
• W4382364355 created "2023-06-29" @default.
• W4382364355 creator A5007098111 @default.
• W4382364355 creator A5008637258 @default.
• W4382364355 creator A5039896971 @default.
• W4382364355 creator A5052692745 @default.
• W4382364355 creator A5056679105 @default.
• W4382364355 creator A5067304730 @default.
• W4382364355 creator A5071377470 @default.
• W4382364355 date "2023-12-01" @default.
• W4382364355 modified "2023-09-26" @default.
• W4382364355 title "PCA-WRKNN-assisted label-free SERS serum analysis platform enabling non-invasive diagnosis of Alzheimer’s disease" @default.
• W4382364355 cites W1870343941 @default.
• W4382364355 cites W1967930873 @default.
• W4382364355 cites W1970710602 @default.
• W4382364355 cites W1977182656 @default.
• W4382364355 cites W1995001633 @default.
• W4382364355 cites W1997178704 @default.
• W4382364355 cites W2057614787 @default.
• W4382364355 cites W2065429003 @default.
• W4382364355 cites W2068837962 @default.
• W4382364355 cites W2083730277 @default.
• W4382364355 cites W2115017507 @default.
• W4382364355 cites W2124569930 @default.
• W4382364355 cites W2134285663 @default.
• W4382364355 cites W2326312798 @default.
• W4382364355 cites W2465584395 @default.
• W4382364355 cites W2808743080 @default.
• W4382364355 cites W2991388975 @default.
• W4382364355 cites W2992555466 @default.
• W4382364355 cites W2997185751 @default.
• W4382364355 cites W2999277653 @default.
• W4382364355 cites W3061854617 @default.
• W4382364355 cites W3135004658 @default.
• W4382364355 cites W3209386356 @default.
• W4382364355 cites W4206430945 @default.
• W4382364355 cites W4221090520 @default.
• W4382364355 cites W4225131055 @default.
• W4382364355 cites W4280652267 @default.
• W4382364355 cites W4281741007 @default.
• W4382364355 cites W4282917562 @default.
• W4382364355 cites W4283718862 @default.
• W4382364355 doi "https://doi.org/10.1016/j.saa.2023.123088" @default.
• W4382364355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37392535" @default.
• W4382364355 hasPublicationYear "2023" @default.
• W4382364355 type Work @default.
• W4382364355 citedByCount "0" @default.
• W4382364355 crossrefType "journal-article" @default.
• W4382364355 hasAuthorship W4382364355A5007098111 @default.
• W4382364355 hasAuthorship W4382364355A5008637258 @default.
• W4382364355 hasAuthorship W4382364355A5039896971 @default.
• W4382364355 hasAuthorship W4382364355A5052692745 @default.
• W4382364355 hasAuthorship W4382364355A5056679105 @default.
• W4382364355 hasAuthorship W4382364355A5067304730 @default.
• W4382364355 hasAuthorship W4382364355A5071377470 @default.
• W4382364355 hasConcept C110879396 @default.
• W4382364355 hasConcept C113196181 @default.
• W4382364355 hasConcept C120665830 @default.
• W4382364355 hasConcept C121332964 @default.
• W4382364355 hasConcept C142724271 @default.
• W4382364355 hasConcept C153180895 @default.
• W4382364355 hasConcept C154945302 @default.
• W4382364355 hasConcept C169573571 @default.
• W4382364355 hasConcept C184880428 @default.
• W4382364355 hasConcept C185592680 @default.
• W4382364355 hasConcept C186060115 @default.
• W4382364355 hasConcept C192562407 @default.
• W4382364355 hasConcept C27438332 @default.
• W4382364355 hasConcept C2779651940 @default.
• W4382364355 hasConcept C2780692498 @default.
• W4382364355 hasConcept C40003534 @default.
• W4382364355 hasConcept C41008148 @default.
• W4382364355 hasConcept C43617362 @default.
• W4382364355 hasConcept C49040817 @default.
• W4382364355 hasConcept C71924100 @default.
• W4382364355 hasConcept C86803240 @default.
• W4382364355 hasConcept C9893847 @default.
• W4382364355 hasConceptScore W4382364355C110879396 @default.
• W4382364355 hasConceptScore W4382364355C113196181 @default.
• W4382364355 hasConceptScore W4382364355C120665830 @default.
• W4382364355 hasConceptScore W4382364355C121332964 @default.
• W4382364355 hasConceptScore W4382364355C142724271 @default.
• W4382364355 hasConceptScore W4382364355C153180895 @default.
• W4382364355 hasConceptScore W4382364355C154945302 @default.
• W4382364355 hasConceptScore W4382364355C169573571 @default.
• W4382364355 hasConceptScore W4382364355C184880428 @default.
• W4382364355 hasConceptScore W4382364355C185592680 @default.
• W4382364355 hasConceptScore W4382364355C186060115 @default.
• W4382364355 hasConceptScore W4382364355C192562407 @default.
• W4382364355 hasConceptScore W4382364355C27438332 @default.
• W4382364355 hasConceptScore W4382364355C2779651940 @default.
• W4382364355 hasConceptScore W4382364355C2780692498 @default.
• W4382364355 hasConceptScore W4382364355C40003534 @default.
• W4382364355 hasConceptScore W4382364355C41008148 @default.
• W4382364355 hasConceptScore W4382364355C43617362 @default.
• W4382364355 hasConceptScore W4382364355C49040817 @default.
• W4382364355 hasConceptScore W4382364355C71924100 @default.
• W4382364355 hasConceptScore W4382364355C86803240 @default.

• next